前额叶-丘脑下θ 信号介导冲突处理过程中的延迟反应

IF 6.7 2区 医学 Q1 NEUROSCIENCES Progress in Neurobiology Pub Date : 2024-04-15 DOI:10.1016/j.pneurobio.2024.102613
Jeong Woo Choi , Mahsa Malekmohammadi , Soroush Niketeghad , Katy A. Cross , Hamasa Ebadi , Amirreza Alijanpourotaghsara , Adam Aron , Ueli Rutishauser , Nader Pouratian
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引用次数: 0

摘要

虽然内侧额叶皮层(MFC)和丘脑下核(STN)分别与冲突监测和行动抑制有关,但目前还缺乏对这些节点的时空和频谱相互作用以及它们如何与运动皮层(M1)相互作用以明确改变冲突期间的运动行为的综合了解。我们在 20 名接受脑深部刺激植入手术治疗帕金森病或肌张力障碍的患者的侧翼任务中记录了颅内前补充运动区(pre-SMA)、M1、STN 和苍白球内肌(GPi)的神经信号。冲突与从前SMA到STN再到M1的局部θ功率的顺序性和因果性增加有关,运动延迟与STNθ功率的增加直接相关,这表明前SMA是监控冲突并向STN发出 "休息 "信号的MFC位置。从 STN 到 M1 的 Theta 传输随后会导致 M1 到 GPi 的 beta 流量在运动前出现短暂增加,从而调节运动网络以启动与冲突相关的动作抑制(即延迟反应)。冲突期间的动作调节依赖于两个不同的回路,即与冲突相关的θ网络和与运动相关的β网络,这两个回路在空间、频谱和时间上是分离的,但它们动态地相互作用以介导运动表现,突显了复杂的平行但又相互作用的运动调节网络。
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Prefrontal-subthalamic theta signaling mediates delayed responses during conflict processing

While medial frontal cortex (MFC) and subthalamic nucleus (STN) have been implicated in conflict monitoring and action inhibition, respectively, an integrated understanding of the spatiotemporal and spectral interaction of these nodes and how they interact with motor cortex (M1) to definitively modify motor behavior during conflict is lacking. We recorded neural signals intracranially across presupplementary motor area (preSMA), M1, STN, and globus pallidus internus (GPi), during a flanker task in 20 patients undergoing deep brain stimulation implantation surgery for Parkinson disease or dystonia. Conflict is associated with sequential and causal increases in local theta power from preSMA to STN to M1 with movement delays directly correlated with increased STN theta power, indicating preSMA is the MFC locus that monitors conflict and signals STN to implement a ‘break.’ Transmission of theta from STN-to-M1 subsequently results in a transient increase in M1-to-GPi beta flow immediately prior to movement, modulating the motor network to actuate the conflict-related action inhibition (i.e., delayed response). Action regulation during conflict relies on two distinct circuits, the conflict-related theta and movement-related beta networks, that are separated spatially, spectrally, and temporally, but which interact dynamically to mediate motor performance, highlighting complex parallel yet interacting networks regulating movement.

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来源期刊
Progress in Neurobiology
Progress in Neurobiology 医学-神经科学
CiteScore
12.80
自引率
1.50%
发文量
107
审稿时长
33 days
期刊介绍: Progress in Neurobiology is an international journal that publishes groundbreaking original research, comprehensive review articles and opinion pieces written by leading researchers. The journal welcomes contributions from the broad field of neuroscience that apply neurophysiological, biochemical, pharmacological, molecular biological, anatomical, computational and behavioral analyses to problems of molecular, cellular, developmental, systems, and clinical neuroscience.
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