右美托咪定抑制接受扁桃体切除术和/或腺样体切除术的学龄前儿童出现谵妄的中位有效剂量:一项剂量-反应回顾性试验

IF 2.3 4区 医学 Q3 PHARMACOLOGY & PHARMACY Dose-Response Pub Date : 2024-04-20 DOI:10.1177/15593258241248919
BaiYun Wei, CuiYu Yu, JinBo Xiao, Huang Xu, Ping Zheng, WeiBing Wang
{"title":"右美托咪定抑制接受扁桃体切除术和/或腺样体切除术的学龄前儿童出现谵妄的中位有效剂量:一项剂量-反应回顾性试验","authors":"BaiYun Wei, CuiYu Yu, JinBo Xiao, Huang Xu, Ping Zheng, WeiBing Wang","doi":"10.1177/15593258241248919","DOIUrl":null,"url":null,"abstract":"The incidence of emergence delirium (ED) is higher in preschool children undergoing tonsillectomy and/or adenoidectomy. The purpose of this study was to determine the median effective dose (ED50) of dexmedetomidine (DEX) for the inhibition of ED in preschool children by using probit regression analysis. A total of 140 anesthesia records were retrieved and divided into seven groups based on the infusion rate of DEX: .2, .25, .3, .35, .4, .45, and .5 μg·kg<jats:sup>−1</jats:sup>·h<jats:sup>−1</jats:sup>. The Pediatric Anesthesia Emergence Delirium Scale (PAEDS) was used to assess ED in preschool children, and ED was defined as a PAEDS score ≥ 10. Probit regression analysis revealed that the ED50 and ED95 of DEX were .31 μg·kg<jats:sup>−1</jats:sup>·h<jats:sup>−1</jats:sup> (95% CI: .29–.35) and .48 μg·kg<jats:sup>−1</jats:sup>·h<jats:sup>−1</jats:sup> (95% CI: .44–.56), respectively. Probit(p) = −2.84 + 9.28 × ln (Dose), (χ<jats:sup>2</jats:sup> = 1.925, P = .859). The PAEDS score was significantly increased in the ED group, and the rate of bradycardia was significantly decreased in the ED group compared with the without ED group (27.3% vs 54.1%, P = .02). DEX can effectively inhibit the ED in preschool children undergoing tonsillectomy and/or adenoidectomy, however, bradycardia was the main complication.","PeriodicalId":11285,"journal":{"name":"Dose-Response","volume":"219 1","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Median Effective Dose of Dexmedetomidine for the Inhibition of Emergence Delirium in Preschool Children Undergoing Tonsillectomy and/or Adenoidectomy: A Retrospective Dose-response Trial\",\"authors\":\"BaiYun Wei, CuiYu Yu, JinBo Xiao, Huang Xu, Ping Zheng, WeiBing Wang\",\"doi\":\"10.1177/15593258241248919\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The incidence of emergence delirium (ED) is higher in preschool children undergoing tonsillectomy and/or adenoidectomy. The purpose of this study was to determine the median effective dose (ED50) of dexmedetomidine (DEX) for the inhibition of ED in preschool children by using probit regression analysis. A total of 140 anesthesia records were retrieved and divided into seven groups based on the infusion rate of DEX: .2, .25, .3, .35, .4, .45, and .5 μg·kg<jats:sup>−1</jats:sup>·h<jats:sup>−1</jats:sup>. The Pediatric Anesthesia Emergence Delirium Scale (PAEDS) was used to assess ED in preschool children, and ED was defined as a PAEDS score ≥ 10. Probit regression analysis revealed that the ED50 and ED95 of DEX were .31 μg·kg<jats:sup>−1</jats:sup>·h<jats:sup>−1</jats:sup> (95% CI: .29–.35) and .48 μg·kg<jats:sup>−1</jats:sup>·h<jats:sup>−1</jats:sup> (95% CI: .44–.56), respectively. Probit(p) = −2.84 + 9.28 × ln (Dose), (χ<jats:sup>2</jats:sup> = 1.925, P = .859). The PAEDS score was significantly increased in the ED group, and the rate of bradycardia was significantly decreased in the ED group compared with the without ED group (27.3% vs 54.1%, P = .02). DEX can effectively inhibit the ED in preschool children undergoing tonsillectomy and/or adenoidectomy, however, bradycardia was the main complication.\",\"PeriodicalId\":11285,\"journal\":{\"name\":\"Dose-Response\",\"volume\":\"219 1\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-04-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dose-Response\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15593258241248919\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dose-Response","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15593258241248919","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

摘要

接受扁桃体切除术和/或腺样体切除术的学龄前儿童出现谵妄(ED)的几率较高。本研究旨在利用 probit 回归分析法确定右美托咪定(DEX)抑制学龄前儿童 ED 的中位有效剂量(ED50)。本研究共检索了 140 份麻醉记录,并根据 DEX 的输注率分为 7 组:.2、.25、.3、.35、.4、.45 和 .5 μg-kg-1-h-1。小儿麻醉后谵妄量表(PAEDS)用于评估学龄前儿童的ED,PAEDS评分≥10分为ED。Probit 回归分析显示,DEX 的 ED50 和 ED95 分别为 0.31 μg-kg-1-h-1 (95% CI: 0.29-.35) 和 0.48 μg-kg-1-h-1 (95% CI: 0.44-.56)。Probit(p) = -2.84 + 9.28 × ln(剂量),(χ2 = 1.925,P = .859)。与无 ED 组相比,ED 组的 PAEDS 评分明显升高,心动过缓发生率明显降低(27.3% vs 54.1%,P = .02)。DEX能有效抑制接受扁桃体切除术和/或腺样体切除术的学龄前儿童的ED,但心动过缓是主要并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The Median Effective Dose of Dexmedetomidine for the Inhibition of Emergence Delirium in Preschool Children Undergoing Tonsillectomy and/or Adenoidectomy: A Retrospective Dose-response Trial
The incidence of emergence delirium (ED) is higher in preschool children undergoing tonsillectomy and/or adenoidectomy. The purpose of this study was to determine the median effective dose (ED50) of dexmedetomidine (DEX) for the inhibition of ED in preschool children by using probit regression analysis. A total of 140 anesthesia records were retrieved and divided into seven groups based on the infusion rate of DEX: .2, .25, .3, .35, .4, .45, and .5 μg·kg−1·h−1. The Pediatric Anesthesia Emergence Delirium Scale (PAEDS) was used to assess ED in preschool children, and ED was defined as a PAEDS score ≥ 10. Probit regression analysis revealed that the ED50 and ED95 of DEX were .31 μg·kg−1·h−1 (95% CI: .29–.35) and .48 μg·kg−1·h−1 (95% CI: .44–.56), respectively. Probit(p) = −2.84 + 9.28 × ln (Dose), (χ2 = 1.925, P = .859). The PAEDS score was significantly increased in the ED group, and the rate of bradycardia was significantly decreased in the ED group compared with the without ED group (27.3% vs 54.1%, P = .02). DEX can effectively inhibit the ED in preschool children undergoing tonsillectomy and/or adenoidectomy, however, bradycardia was the main complication.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Dose-Response
Dose-Response PHARMACOLOGY & PHARMACY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
4.90
自引率
4.00%
发文量
140
审稿时长
>12 weeks
期刊介绍: Dose-Response is an open access peer-reviewed online journal publishing original findings and commentaries on the occurrence of dose-response relationships across a broad range of disciplines. Particular interest focuses on experimental evidence providing mechanistic understanding of nonlinear dose-response relationships.
期刊最新文献
Zeatin Elicits Premature Erythrocyte Senescence Through Calcium and Oxidative Stress Mediated by the NOS/PKC/CK1α Signaling Axis. Identification, Characterization and Anti-inflammatory Activity of a New Flavonoid From Hibiscus mutabilis L. INWORKS and Hiroshima/Nagasaki Leukaemia Results. Antimicrobial and Hepatoprotective Properties of Pods of Acacia nilotica (L.) Willd. ex Delile: In Vivo and In Silico Approaches. Identification of Secondary Metabolites of Cyperus rotundus L. and Dose-dependent Effects on Antioxidant Activity and Carbohydrate Digestion Enzymes.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1