Jiachen Liu, Qingjiang Xu, Xin Wang, Xiaoya Shang, Nan Wang
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引用次数: 0
摘要
从红曲米乙醇提取物乙酸乙酯部分中强烈抑制 3-羟基-3-甲基戊二酰-CoA 还原酶的馏分中分离出了三种新的独活素类似物：3,6-二羟基独活素 P (1)、6-甲氧基独活素 S (2)和 6-甲氧基脱水独活素 S (3)。通过一维和二维核磁共振实验、质谱分析以及已知的文献报告，确定了它们的结构。
Structural elucidation and complete NMR spectral assignments of Monascus monacolin analogues
Three new monacolin analogues, 3,6-dihydroxy-monacolin P (1), 6-methoxy monacolin S (2), and 6-methoxy dehydromonacolin S (3), were isolated from a fraction that strongly inhibited 3-hydroxy-3-methylglutaryl-CoA reductase from the ethyl acetate portion of red yeast rice ethanol extract. Their structures were determined through a combination of 1D and 2D NMR experiments, mass spectrometry analysis, and known literature reports.
期刊介绍：
MRC is devoted to the rapid publication of papers which are concerned with the development of magnetic resonance techniques, or in which the application of such techniques plays a pivotal part. Contributions from scientists working in all areas of NMR, ESR and NQR are invited, and papers describing applications in all branches of chemistry, structural biology and materials chemistry are published.
The journal is of particular interest not only to scientists working in academic research, but also those working in commercial organisations who need to keep up-to-date with the latest practical applications of magnetic resonance techniques.
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