含载脂蛋白 B 脂蛋白的生物合成与代谢

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS Annual review of nutrition Pub Date : 2024-04-18 DOI:10.1146/annurev-nutr-062222-020716
Jan Borén, Marja-Riitta Taskinen, Chris J. Packard
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引用次数: 0

摘要

人类遗传学的最新进展以及大量流行病学、临床前和临床试验证据都有力地证明,富含甘油三酯的脂蛋白(TRLs)与动脉粥样硬化性心血管疾病之间存在因果关系。因此,TRLs 的分泌和代谢对心血管健康有着重大影响。这些知识强调了了解极低密度脂蛋白(VLDL)和乳糜微粒生物生成的分子机制和调控的重要性。幸运的是,人们对极低密度脂蛋白的细胞内组装、贩运、降解和分泌的兴趣再次升温,从而产生了许多突破性的分子见解。此外,与甘油三酯代谢相关的分子控制机制的鉴定也大大推进了我们对 TRLs 复杂代谢的了解。在本综述中,我们将探讨 TRLs 组装、分泌和代谢方面的最新进展。我们还讨论了高甘油三酯血症的现有治疗策略。
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Biosynthesis and Metabolism of ApoB-Containing Lipoproteins
Recent advances in human genetics, together with a substantial body of epidemiological, preclinical and clinical trial evidence, strongly support a causal relationship between triglyceride-rich lipoproteins (TRLs) and atherosclerotic cardiovascular disease. Consequently, the secretion and metabolism of TRLs have a significant impact on cardiovascular health. This knowledge underscores the importance of understanding the molecular mechanisms and regulation of very-low-density lipoprotein (VLDL) and chylomicron biogenesis. Fortunately, there has been a resurgence of interest in the intracellular assembly, trafficking, degradation, and secretion of VLDL, leading to many ground-breaking molecular insights. Furthermore, the identification of molecular control mechanisms related to triglyceride metabolism has greatly advanced our understanding of the complex metabolism of TRLs. In this review, we explore recent advances in the assembly, secretion, and metabolism of TRLs. We also discuss available treatment strategies for hypertriglyceridemia.
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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
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