Gitte Zels , Karen Van Baelen , Maxim De Schepper , Kristien Borremans , Tatjana Geukens , Edoardo Isnaldi , Hava Izci , Sophia Leduc , Amena Mahdami , Marion Maetens , Ha Linh Nguyen , Anirudh Pabba , François Richard , Josephine Van Cauwenberge , Ann Smeets , Ines Nevelsteen , Patrick Neven , Hans Wildiers , Wouter Van Den Bogaert , Giuseppe Floris , Christine Desmedt
{"title":"无特殊类型和小叶混合型原发性乳腺癌的转移灶显示出唯一的小叶组织学特征","authors":"Gitte Zels , Karen Van Baelen , Maxim De Schepper , Kristien Borremans , Tatjana Geukens , Edoardo Isnaldi , Hava Izci , Sophia Leduc , Amena Mahdami , Marion Maetens , Ha Linh Nguyen , Anirudh Pabba , François Richard , Josephine Van Cauwenberge , Ann Smeets , Ines Nevelsteen , Patrick Neven , Hans Wildiers , Wouter Van Den Bogaert , Giuseppe Floris , Christine Desmedt","doi":"10.1016/j.breast.2024.103732","DOIUrl":null,"url":null,"abstract":"<div><p>Primary tumors with a mixed invasive breast carcinoma of no-special type (IBC-NST) and invasive lobular cancer (ILC) histology are present in approximately five percent of all patients with breast cancer and are understudied at the metastatic level. Here, we characterized the histology of metastases from two patients with primary mixed IBC-NST/ILC from the postmortem tissue donation program UPTIDER (NCT04531696). The 14 and 43 metastatic lesions collected at autopsy had morphological features and E-cadherin staining patterns consistent with pure ILC. While our findings still require further validation, they may challenge current clinical practice and imaging modalities used in these patients.</p></div>","PeriodicalId":9093,"journal":{"name":"Breast","volume":"75 ","pages":"Article 103732"},"PeriodicalIF":5.7000,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0960977624000638/pdfft?md5=64943219ac0bd86fe556bd4ec789168b&pid=1-s2.0-S0960977624000638-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Metastases of primary mixed no-special type and lobular breast cancer display an exclusive lobular histology\",\"authors\":\"Gitte Zels , Karen Van Baelen , Maxim De Schepper , Kristien Borremans , Tatjana Geukens , Edoardo Isnaldi , Hava Izci , Sophia Leduc , Amena Mahdami , Marion Maetens , Ha Linh Nguyen , Anirudh Pabba , François Richard , Josephine Van Cauwenberge , Ann Smeets , Ines Nevelsteen , Patrick Neven , Hans Wildiers , Wouter Van Den Bogaert , Giuseppe Floris , Christine Desmedt\",\"doi\":\"10.1016/j.breast.2024.103732\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Primary tumors with a mixed invasive breast carcinoma of no-special type (IBC-NST) and invasive lobular cancer (ILC) histology are present in approximately five percent of all patients with breast cancer and are understudied at the metastatic level. Here, we characterized the histology of metastases from two patients with primary mixed IBC-NST/ILC from the postmortem tissue donation program UPTIDER (NCT04531696). The 14 and 43 metastatic lesions collected at autopsy had morphological features and E-cadherin staining patterns consistent with pure ILC. While our findings still require further validation, they may challenge current clinical practice and imaging modalities used in these patients.</p></div>\",\"PeriodicalId\":9093,\"journal\":{\"name\":\"Breast\",\"volume\":\"75 \",\"pages\":\"Article 103732\"},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2024-04-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0960977624000638/pdfft?md5=64943219ac0bd86fe556bd4ec789168b&pid=1-s2.0-S0960977624000638-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Breast\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0960977624000638\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Breast","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0960977624000638","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Metastases of primary mixed no-special type and lobular breast cancer display an exclusive lobular histology
Primary tumors with a mixed invasive breast carcinoma of no-special type (IBC-NST) and invasive lobular cancer (ILC) histology are present in approximately five percent of all patients with breast cancer and are understudied at the metastatic level. Here, we characterized the histology of metastases from two patients with primary mixed IBC-NST/ILC from the postmortem tissue donation program UPTIDER (NCT04531696). The 14 and 43 metastatic lesions collected at autopsy had morphological features and E-cadherin staining patterns consistent with pure ILC. While our findings still require further validation, they may challenge current clinical practice and imaging modalities used in these patients.
期刊介绍：
The Breast is an international, multidisciplinary journal for researchers and clinicians, which focuses on translational and clinical research for the advancement of breast cancer prevention, diagnosis and treatment of all stages.
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