严重高甘油三酯血症患者的颈动脉内膜厚度

IF 1.4 Q3 PERIPHERAL VASCULAR DISEASE Atherosclerosis plus Pub Date : 2024-04-21 DOI:10.1016/j.athplu.2024.04.001
Maud Ahmad , Brooke A. Kennedy , Surim Son , Adam D. McIntyre , Julieta Lazarte , Jian Wang , Robert A. Hegele
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引用次数: 0

摘要

背景和目的严重的高甘油三酯血症(HTG)定义为血浆甘油三酯(TG)浓度大于或等于 10 mmol/L,这种情况相对少见,其对动脉粥样硬化性心血管疾病(ASCVD)风险的影响仍不明确。我们评估了重度高血脂症与 ASCVD 标志物--颈动脉内膜中层厚度(IMT)之间的关系:我们研究了三个临床队列:88 名重度高胆固醇血症患者(平均 TG 水平为 20.6 mmol/L)、271 名作为对比组的家族性高胆固醇血症(FH)患者和 70 名血脂正常的对照组。采用标准化超声成像测量颈动脉内中膜厚度。统计分析采用单因素方差分析(ANOVA)比较平均IMT值,协方差分析(ANCOVA)调整混杂变量,特别是年龄和性别,以及变量之间的斯皮尔曼配对相关分析。结论我们的研究结果表明,重度高血压患者的总胆固醇极度升高与颈动脉内径无明显关系,这与高脂血症患者的颈动脉内径增大形成鲜明对比。这些发现为重度高血压与 ASCVD 风险之间的复杂关系增添了新的视角。
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Carotid intimamedia thickness in patients with severe hypertriglyceridemia

Background and aims

Severe hypertriglyceridemia (HTG), defined as plasma triglyceride (TG) concentration > 10 mmol/L, is relatively uncommon, and its implications for atherosclerotic cardiovascular disease (ASCVD) risk remain somewhat unclear. We evaluated the association between severe HTG and carotid intima-media thickness (IMT), a marker for ASCVD.

Methods

We studied three clinical cohorts: 88 patients with severe HTG (mean TG level 20.6 mmol/L), 271 patients with familial hypercholesterolemia (FH) as a contrast group, and 70 normolipidemic controls. Carotid IMT was measured using standardized ultrasound imaging. Statistical analysis was conducted using one-way analysis of variance (ANOVA) to compare mean IMT values, analysis of covariance (ANCOVA) to adjust for confounding variables, specifically age and sex, as well as Spearman pairwise correlation analysis between variables.

Results

Unadjusted mean carotid IMT was greater in severe HTG and FH groups compared to controls, however, this was no longer significant for severe HTG after adjustment for age and sex. In contrast, adjusted carotid IMT remained significantly different between the FH and control groups.

Conclusions

Our findings suggest that extreme TG elevations in severe HTG patients are not significantly associated with carotid IMT, in contrast to the increased IMT seen in FH patients. These findings add perspective to the complex relationship between severe HTG and ASCVD risk.

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来源期刊
Atherosclerosis plus
Atherosclerosis plus Cardiology and Cardiovascular Medicine
CiteScore
2.60
自引率
0.00%
发文量
0
审稿时长
66 days
期刊最新文献
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