Mirela Ramacciotti, Raimundo da Silva Soares Junior, João Ricardo Sato, M. Gualtieri
{"title":"在早年样本的抑制控制任务中,fNIRS显示左侧OFC激活:将压力反应与认知功能和大脑激活结合起来。","authors":"Mirela Ramacciotti, Raimundo da Silva Soares Junior, João Ricardo Sato, M. Gualtieri","doi":"10.1159/000539023","DOIUrl":null,"url":null,"abstract":"INTRODUCTION\nPrevious functional near-infrared (fNIRS) studies using Go/No-Go (GNG) tasks have focused on brain activation in relation to cognitive processes, particularly inhibitory control (IC). The results of these studies commonly describe right hemispheric engagement of the dorsolateral, ventromedial or inferior frontal regions of the prefrontal cortex (PFC). Considering that typical healthy cognitive development is negatively correlated with higher cortisol levels (which may alter brain development), the overarching aim of the current study was to investigate how elevated stress (due to unforeseeable events such as the pandemic) impacts early cognitive development.\n\n\nMETHOD\nIn this study, we examined fNIRS data collected from a sample of children (aged 2 - 4 years) during a GNG task relative to the response to stressors measured via hair cortisol concentrations. We acquired data in an ecological setting (Early Childhood Education and Care) during the coronavirus pandemic.\n\n\nRESULTS\nWe found that children with higher stress levels and a less efficient inhibitory control recruited more neural terrain and our group-level analysis indicated activation in the left orbitofrontal area during IC performance.\n\n\nCONCLUSIONS\nA contextual stressor may disrupt accuracy in the executive function of inhibitory control early in development. More research efforts are needed to understand better how an orbitofrontal network subserves goal-directed behavior.","PeriodicalId":50585,"journal":{"name":"Developmental Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Left OFC activation in fNIRS during an inhibitory control task in an early years sample: integrating stress responses with cognitive function and brain activation.\",\"authors\":\"Mirela Ramacciotti, Raimundo da Silva Soares Junior, João Ricardo Sato, M. Gualtieri\",\"doi\":\"10.1159/000539023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"INTRODUCTION\\nPrevious functional near-infrared (fNIRS) studies using Go/No-Go (GNG) tasks have focused on brain activation in relation to cognitive processes, particularly inhibitory control (IC). The results of these studies commonly describe right hemispheric engagement of the dorsolateral, ventromedial or inferior frontal regions of the prefrontal cortex (PFC). Considering that typical healthy cognitive development is negatively correlated with higher cortisol levels (which may alter brain development), the overarching aim of the current study was to investigate how elevated stress (due to unforeseeable events such as the pandemic) impacts early cognitive development.\\n\\n\\nMETHOD\\nIn this study, we examined fNIRS data collected from a sample of children (aged 2 - 4 years) during a GNG task relative to the response to stressors measured via hair cortisol concentrations. We acquired data in an ecological setting (Early Childhood Education and Care) during the coronavirus pandemic.\\n\\n\\nRESULTS\\nWe found that children with higher stress levels and a less efficient inhibitory control recruited more neural terrain and our group-level analysis indicated activation in the left orbitofrontal area during IC performance.\\n\\n\\nCONCLUSIONS\\nA contextual stressor may disrupt accuracy in the executive function of inhibitory control early in development. More research efforts are needed to understand better how an orbitofrontal network subserves goal-directed behavior.\",\"PeriodicalId\":50585,\"journal\":{\"name\":\"Developmental Neuroscience\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Developmental Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000539023\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DEVELOPMENTAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000539023","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
Left OFC activation in fNIRS during an inhibitory control task in an early years sample: integrating stress responses with cognitive function and brain activation.
INTRODUCTION
Previous functional near-infrared (fNIRS) studies using Go/No-Go (GNG) tasks have focused on brain activation in relation to cognitive processes, particularly inhibitory control (IC). The results of these studies commonly describe right hemispheric engagement of the dorsolateral, ventromedial or inferior frontal regions of the prefrontal cortex (PFC). Considering that typical healthy cognitive development is negatively correlated with higher cortisol levels (which may alter brain development), the overarching aim of the current study was to investigate how elevated stress (due to unforeseeable events such as the pandemic) impacts early cognitive development.
METHOD
In this study, we examined fNIRS data collected from a sample of children (aged 2 - 4 years) during a GNG task relative to the response to stressors measured via hair cortisol concentrations. We acquired data in an ecological setting (Early Childhood Education and Care) during the coronavirus pandemic.
RESULTS
We found that children with higher stress levels and a less efficient inhibitory control recruited more neural terrain and our group-level analysis indicated activation in the left orbitofrontal area during IC performance.
CONCLUSIONS
A contextual stressor may disrupt accuracy in the executive function of inhibitory control early in development. More research efforts are needed to understand better how an orbitofrontal network subserves goal-directed behavior.
期刊介绍:
''Developmental Neuroscience'' is a multidisciplinary journal publishing papers covering all stages of invertebrate, vertebrate and human brain development. Emphasis is placed on publishing fundamental as well as translational studies that contribute to our understanding of mechanisms of normal development as well as genetic and environmental causes of abnormal brain development. The journal thus provides valuable information for both physicians and biologists. To meet the rapidly expanding information needs of its readers, the journal combines original papers that report on progress and advances in developmental neuroscience with concise mini-reviews that provide a timely overview of key topics, new insights and ongoing controversies. The editorial standards of ''Developmental Neuroscience'' are high. We are committed to publishing only high quality, complete papers that make significant contributions to the field.