具有增强磁性能的 Fe3O4/CoFe2O4 核壳纳米粒子在热疗中的应用

V. T. K. Oanh, L. H. Nguyen, L. Phong, M. T. T. Trang, H. P. Thu, N. X. Truong, N. X. Ca, P. H. Nam, D. H. Manh
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引用次数: 0

摘要

通过热分解法以种子为介质的生长方式制备了不同壳厚度的 Fe3O4/CoFe2O4 核/壳纳米粒子。使用聚(马来酸酐-alt-1-十八碳烯)(PMAO)进行配体交换,从合成的纳米粒子中制备出水磁性流体。利用 X 射线衍射 (XRD)、透射电子显微镜 (TEM) 和 Quantum Design PPMS VersaLab 对样品的形态和磁性能进行了表征。XRD 结果表明,所有颗粒都是单相尖晶石结构,平均晶粒大小在 11-17 纳米之间。在 TEM 图像中,所有颗粒都呈球形,其大小与 XRD 计算出的结果相似。磁性测量是在不同温度(50 - 300 K)、30 kOe 条件下进行的。结果表明,随着厚度不同的硬磁壳的形成,饱和磁化(M s)和矫顽力(H C)显著增加。动态光散射(DLS)分析显示,铁流体的分布很窄,zeta 电位在 -16 至 -35 mV 之间,这表明铁流体具有良好的稳定性。FOC3/PMAO ferrofluid 的 SAR 值最高,为 372.02 W g-1,在 10 至 100 μg ml-1 的不同浓度下,对 Hep-G2 细胞系进行了细胞毒性测试。只有不到 30% 的细胞受到抑制,这表明 FOC3/PMAO 颗粒在这些测试浓度下具有低毒性。因此,与 Fe3O4 核纳米粒子相比,这些合成的核/壳纳米粒子具有粒度均匀、饱和磁化率高、稳定性好以及比吸收率(SAR)提高五倍等特点,在热疗和磁共振成像(MRI)方面的应用前景非常广阔。
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Fe3O4/CoFe2O4 core-shell nanoparticles with enhanced magnetic properties for hyperthermia application
Fe3O4/CoFe2O4 core/shell nanoparticles with varying shell thickness were fabricated by seed-mediated growth via thermal decomposition method. Ligand exchange process using poly(maleic anhydride-alt-1-octadecene) (PMAO) was performed to prepare the aqueous magnetic fluids from the as-synthesised nanoparticles. X-ray diffraction (XRD), transmission electron microscopy (TEM) and Quantum Design PPMS VersaLab were utilised to characterise morphological and magnetic properties of the sample. XRD results showed that all the particles were single phase with spinel structure and the average crystallite size in the range of 11–17 nm. All particles were spherical in TEM images with similar size compared to results calculated from XRD. Magnetic measurements were performed at different temperatures (50 − 300 K) at 30 kOe. The result showed that the saturation magnetisation (M s) and coercivity (H C) were significantly increased with the formation of hard magnetic shell with varying thickness. The dynamic light scattering (DLS) analysis presented a narrow distribution and zeta potential of −16 to −35 mV, indicating a good stability of the ferrofluids. The cytotoxicity of the FOC3/PMAO ferrofluid, which has the highest SAR value of 372.02 W g−1, was tested on Hep-G2 cell line at different concentrations from 10 to 100 μg ml−1. Less than 30% of the cell was inhibited, indicating that the FOC3/PMAO particles have low toxicity at these tested concentrations. Thus, these as-synthesised core/shell nanoparticles with uniform particle size, high saturation magnetisation, good stability and five-time increased specific absorption rate (SAR) compared to the Fe3O4 core nanoparticles are very promising in hyperthermia and magnetic resonance imaging (MRI) applications.
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来源期刊
Advances in Natural Sciences: Nanoscience and Nanotechnology
Advances in Natural Sciences: Nanoscience and Nanotechnology Engineering-Industrial and Manufacturing Engineering
CiteScore
3.80
自引率
0.00%
发文量
60
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