Victoria M. Garcia, A. C. M. Silva, R. Gontijo, Andréa Vidal Ferreira
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引用次数: 0
摘要
核医学是一种在巴西和世界范围内发展迅速的医学模式,它为疾病的诊断和治疗带来了新的放射性药物和技术,使诊断和治疗更加有效和准确。在开发用于正电子发射断层扫描(PET)的新型放射性药物时,临床前研究步骤主要使用小动物专用 PET 扫描仪。为此,必须进行质量控制测试,以确保设备的效率。因此,这项工作旨在评估 CDTN 小型动物 PET 扫描仪使用同位素 68Ga 的空间分辨率。为此,使用了微型 PET 热棒模型和商用 68Ge/68Ga 发生器来获取 PET 图像。对模拟器的 68Ga-PET 图像进行了定性和定量分析,结果显示,使用 68Ga 的系统的空间分辨率为 3.5 毫米。
Resolução espacial de um tomógrafo PET de pequenos animais usando o isótopo 68Ga
Nuclear Medicine is a modality that has been growing a lot in Brazil and in the world, bringing new radiopharmaceuticals and technologies for the diagnosis and treatment of diseases, making them more effective and accurate. In the development of new radiopharmaceuticals for use in positron emission tomography (PET), the preclinical studies step largely uses PET scanners dedicated to small animals. To achieve this, quality control tests must be carried out to ensure the efficiency of the equipment. Thus, this work aimed to evaluate the spatial resolution of the small animals PET scanner of the CDTN using the isotope 68Ga. In this sense, a microPET hot rod phantom and a commercial 68Ge/68Ga generator were used to obtain PET images. The analysis of the 68Ga-PET images of the simulator was carried out qualitatively and quantitatively and revealed that the spatial resolution of the system using the 68Ga is 3.5 mm.