COVID-19后病程的心血管预测因素:一项队列研究的结果

V. Podzolkov, A. E. Bragina, A. Tarzimanova, I. Shvedov, E. S. Ogibenina, M. A. Avanesyan, A. S. Fomin
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引用次数: 0

摘要

目的评估作为2019年冠状病毒病(COVID-19)后综合征预测因素的心血管风险因素。这项前瞻性队列研究纳入了经临床或实验室确诊为COVID-19的大学医院收治的成年患者。入院时评估了一系列心血管风险因素,包括心-踝血管指数(CAVI)。出院后,对患者进行了为期 6 个月的观察。然后,从电子病历和出院摘要中收集 COVID-19 后的病程数据。采用多变量逻辑回归评估潜在预测因素与结果之间的关联,并计算赔率(OR)和 95% 置信区间(95% CI)以评估关联强度。统计显著性水平为P<0.05。最终分析包括 125 名患者(68 名女性,占 54.4%)。中位年龄为 59.0 [50.5, 71.0]岁。32.8%的患者被诊断为 COVID-19 后综合征。最常见的症状是乏力(19.2%)、头痛(11.2%)和气短(10.4%)。在多变量分析中,CAVI ≥9.5、入院时收缩压(SBP)和肾小球滤过率(GFR)升高与 COVID-19 后综合征相关,OR 值分别为 2,415 (95% CI 1,174-2,846), 1,045 (95% CI 1,010-1,082), 0,971 (95% CI 0,946-0,998) 。年龄(OR 1,056,95% CI 1,009-1,105)和体重指数(OR 1,132,95% CI 1,027-1,248)与COVID-19后新诊断的疾病或现有慢性病的恶化有关。结论:SBP、CAVI 和 GFR 等客观指标可能是后 COVID-19 综合征的预测指标,而年龄和体重指数与后 COVID-19 期间慢性疾病的不良病程有关。
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Cardiovascular predictors of the post-COVID-19 course: results of a cohort study
Aim. To evaluate cardiovascular risk factors as predictors of the post-coronavirus disease 2019 (COVID-19) syndrome.Material and methods. This prospective cohort study included adult patients admitted to a university hospital with a clinically or laboratory-confirmed diagnosis of COVID-19. A number of cardiovascular risk factors were assessed at admission, including the Cardio-Ankle Vascular Index (CAVI). After hospital discharge, patients were observed for 6 months. Then, data on the course of the post-COVID-19 period was collected from electronic medical records and discharge summaries. Two following outcomes were assessed: the development of post-COVID-19 syndrome and the development of newly diagnosed diseases or worsening of existing chronic diseases in the post-COVID-19 period.Multivariable logistic regression was used to assess the association between potential predictors and outcomes, and odds ratios (OR) with 95% confidence intervals (95% CI) were calculated to assess the association strength. The statistical significance level was p<0,05.Results. The final analysis included 125 patients (68 (54,4%) women). The median age was 59,0 [50,5, 71,0] years. Post-COVID-19 syndrome was diagnosed in 32,8% of patients. The most common symptoms were weakness (19,2%), headaches (11,2%) and shortness of breath (10,4%). In multivariate analysis, CAVI ≥9,5, increased systolic blood pressure (SBP) and glomerular filtration rate (GFR) on admission were associated with the post-COVID-19 syndrome, with an OR of 2,415 (95% CI 1,174-2,846), 1,045 (95% CI 1,010-1,082), 0,971 (95% CI 0,946-0,998), respectively. Age (OR 1,056, 95% CI 1,009-1,105) and body mass index (OR 1,132, 95% CI 1,027-1,248) were associated with newly diagnosed diseases or worsening of existing chronic diseases in the post-COVID-19 period.Conclusion. Objective indicators such as SBP, CAVI and GFR may be predictors of post-COVID-19 syndrome, and age and body mass index are associated with the unfavorable course of chronic diseases in the post-COVID-19 period.
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来源期刊
Russian Journal of Cardiology
Russian Journal of Cardiology Medicine-Cardiology and Cardiovascular Medicine
CiteScore
2.20
自引率
0.00%
发文量
185
审稿时长
1 months
期刊介绍: Russian Journal of Cardiology has been issued since 1996. The language of this publication is Russian, with tables of contents and abstracts of all articles presented in English as well. Editor-in-Chief: Prof. Eugene V.Shlyakhto, President of the Russian Society of Cardiology. The aim of the journal is both scientific and practical, also with referring to organizing matters of the Society. The best of all cardiologic research in Russia is submitted to the Journal. Moreover, it contains useful tips and clinical examples for practicing cardiologists. Journal is peer-reviewed, with multi-stage editing. The editorial board is presented by the leading cardiologists from different cities of Russia.
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