介入性炎症性肠病:当前和未来的实践。

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-04-16 DOI:10.1097/MOG.0000000000001028
Benjamin Clement, Juan Reyes Genere
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引用次数: 0

摘要

综述目的炎症性肠病(IBD)与几种描述详尽的肿瘤性和结构性并发症有关。尽管在医疗管理方面取得了长足进步,但疾病患病率的增加、医疗障碍和药物难治性表型导致并发症不断出现。内窥镜技术和工艺的进步使得微创方法成为可能,而这在历史上是需要手术治疗的。在这篇文章中,我们回顾了内镜 IBD 干预治疗的现状和未来。近期发现内镜切除术是治疗常规和复杂结肠炎相关性发育不良的一线治疗方法。支持内镜粘膜下剥离术的证据越来越多,但评估改良内镜粘膜切除技术或混合内镜粘膜下剥离术的研究却很少。相对于球囊扩张术,内镜下狭窄切除术和支架置入术的位置也更加明确,因此我们对如何更好地治疗纤维狭窄性疾病也有了更清晰的认识。总结尽管仍存在重要的知识差距,但内镜疗法在 IBD 中的应用已更加完善,尤其是在结肠炎相关发育不良和狭窄的治疗中。内窥镜在肛周疾病和克罗恩病其他穿透性表现方面的适应症带来了令人兴奋的发展机遇。
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Interventional inflammatory bowel disease: current and future practice.
PURPOSE OF REVIEW Inflammatory bowel diseases (IBD) are associated with several well described neoplastic and structural complications. Increasing disease prevalence, healthcare barriers, and medication refractory phenotypes contribute to ongoing complications despite significant strides in medical management. Enhancements in endoscopic technology and techniques have allowed a minimally invasive approach for what has historically required surgery. In this article, we review the current and future landscape of endoscopic IBD intervention. RECENT FINDINGS Endoscopic resection is the first line for managing conventional and complex colitis-associated dysplasia. Evidence supporting endoscopic submucosal dissection is mounting, yet there is a paucity of studies evaluating modified endoscopic mucosal resection techniques or hybrid endoscopic submucosal dissection. We also have more clarity in how best to approach fibrostenotic disease, as we learn how to position endoscopic stricturotomy and stenting, relative to balloon dilation. Finally, applications in managing penetrating and postsurgical complications have been described, but still require further study. SUMMARY While important knowledge gaps still exist, the application of endoscopic therapies in IBD is more refined, especially within the management of colitis-associated dysplasia and strictures. The indications for endoscopy in perianal disease and other penetrating manifestations of Crohn's disease presents exciting opportunities for growth.
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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