风疹病毒疫苗诱发的肉芽肿：共济失调-特朗日综合征患儿的一个病例

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-04-11 DOI:10.4081/dr.2024.9864

Florine Le Lay, Marianna Deparis, Sylvie Fraitag, Anne Dompmartin

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引用次数: 0

摘要

共济失调毛细血管扩张症（AT）是一种罕见的常染色体隐性原发性免疫缺陷病（PID），由参与 DNA 修复的 ATM 基因突变引起。我们描述了一个在儿童接种疫苗后出现皮肤肉芽肿的年轻女孩的病例。免疫组化显示，肉芽肿由风疹病毒疫苗诱发。这一发现提出了免疫力低下儿童接种风疹活疫苗株的安全性问题。

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Rubella virus vaccine-induced granulomas: a case in children with ataxia-telangiectasia

Ataxia telangiectasia (AT) is a rare autosomal recessive primary immunodeficiency disorder (PID) resulting from a mutation in the ATM gene, which is involved in DNA repair. We describe the case of a young girl with cutaneous granulomas that developed after childhood vaccinations. Immunohistochemistry revealed granulomas induced by the rubella virus vaccine. This finding raises the question of live rubella vaccine strains safety in immunocompromised children.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.