M. Guth, Corinne Pilorget, Marie Lefevre, Astrid Coste, A. Danjou, B. Dananché, D. Praud, O. Pérol, Myriam Daudin, Marie-Ange Clarotti, Stéphanie Lattes, Céline Bouillon, Adèle Paul, J. Schüz, Louis Bujan, A. Olsson, Béatrice Fervers, B. Charbotel
{"title":"有机溶剂的职业暴露与睾丸生殖细胞肿瘤的发病风险(TESTIS 研究):综合暴露评估对风险估计的影响。","authors":"M. Guth, Corinne Pilorget, Marie Lefevre, Astrid Coste, A. Danjou, B. Dananché, D. Praud, O. Pérol, Myriam Daudin, Marie-Ange Clarotti, Stéphanie Lattes, Céline Bouillon, Adèle Paul, J. Schüz, Louis Bujan, A. Olsson, Béatrice Fervers, B. Charbotel","doi":"10.5271/sjweh.4161","DOIUrl":null,"url":null,"abstract":"OBJECTIVES\nEtiological factors of testicular germ cell tumors (TGCT) remain largely unknown, but a causal role of occupational exposures to solvents has been suggested. Previous studies analyzing these exposures reported discordant results, potentially related to exposure assessment methods. The aim of this study was to investigate the role of occupational exposure to solvents on the risk of developing TGCT among young men.\n\n\nMETHODS\nThis study examined occupational exposures to solvents and TGCT risk based on the lifetime work histories of 454 cases and 670 controls, aged 18-45 years, of the French national TESTIS case-control study. Solvent exposure was estimated using: (i) exposure assignment by job-exposure matrix (JEM) and (ii) JEM combined with self-reported exposure data from specific questionnaires (SQ) and expert assessment (EA). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression models.\n\n\nRESULTS\nBoth approaches (JEM and JEM+SQ+EA) showed a consistent association between TGCT and trichloroethylene exposure (exposed versus not exposed; JEM=OR 1.80 [95% confidence interval (CI) 1.12-2.90] and JEM+SQ+EA= OR 2.59 (95% CI 1.42-4.72). Both approaches also observed positive associations with ketone esters and fuels & petroleum-based solvents.\n\n\nCONCLUSION\nThe results suggest that some organic solvents might be involved in the pathogenesis of TGCT among occupationally exposed men. The combined use of JEM+SQ+EA seemed to limit misclassification by considering individual exposure variability and is, therefore, an appealing approach to assess occupational exposures in epidemiological studies.","PeriodicalId":21528,"journal":{"name":"Scandinavian journal of work, environment & health","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation.\",\"authors\":\"M. Guth, Corinne Pilorget, Marie Lefevre, Astrid Coste, A. Danjou, B. Dananché, D. Praud, O. Pérol, Myriam Daudin, Marie-Ange Clarotti, Stéphanie Lattes, Céline Bouillon, Adèle Paul, J. Schüz, Louis Bujan, A. Olsson, Béatrice Fervers, B. Charbotel\",\"doi\":\"10.5271/sjweh.4161\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"OBJECTIVES\\nEtiological factors of testicular germ cell tumors (TGCT) remain largely unknown, but a causal role of occupational exposures to solvents has been suggested. Previous studies analyzing these exposures reported discordant results, potentially related to exposure assessment methods. The aim of this study was to investigate the role of occupational exposure to solvents on the risk of developing TGCT among young men.\\n\\n\\nMETHODS\\nThis study examined occupational exposures to solvents and TGCT risk based on the lifetime work histories of 454 cases and 670 controls, aged 18-45 years, of the French national TESTIS case-control study. Solvent exposure was estimated using: (i) exposure assignment by job-exposure matrix (JEM) and (ii) JEM combined with self-reported exposure data from specific questionnaires (SQ) and expert assessment (EA). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression models.\\n\\n\\nRESULTS\\nBoth approaches (JEM and JEM+SQ+EA) showed a consistent association between TGCT and trichloroethylene exposure (exposed versus not exposed; JEM=OR 1.80 [95% confidence interval (CI) 1.12-2.90] and JEM+SQ+EA= OR 2.59 (95% CI 1.42-4.72). Both approaches also observed positive associations with ketone esters and fuels & petroleum-based solvents.\\n\\n\\nCONCLUSION\\nThe results suggest that some organic solvents might be involved in the pathogenesis of TGCT among occupationally exposed men. The combined use of JEM+SQ+EA seemed to limit misclassification by considering individual exposure variability and is, therefore, an appealing approach to assess occupational exposures in epidemiological studies.\",\"PeriodicalId\":21528,\"journal\":{\"name\":\"Scandinavian journal of work, environment & health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-04-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scandinavian journal of work, environment & health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5271/sjweh.4161\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scandinavian journal of work, environment & health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5271/sjweh.4161","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation.
OBJECTIVES
Etiological factors of testicular germ cell tumors (TGCT) remain largely unknown, but a causal role of occupational exposures to solvents has been suggested. Previous studies analyzing these exposures reported discordant results, potentially related to exposure assessment methods. The aim of this study was to investigate the role of occupational exposure to solvents on the risk of developing TGCT among young men.
METHODS
This study examined occupational exposures to solvents and TGCT risk based on the lifetime work histories of 454 cases and 670 controls, aged 18-45 years, of the French national TESTIS case-control study. Solvent exposure was estimated using: (i) exposure assignment by job-exposure matrix (JEM) and (ii) JEM combined with self-reported exposure data from specific questionnaires (SQ) and expert assessment (EA). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression models.
RESULTS
Both approaches (JEM and JEM+SQ+EA) showed a consistent association between TGCT and trichloroethylene exposure (exposed versus not exposed; JEM=OR 1.80 [95% confidence interval (CI) 1.12-2.90] and JEM+SQ+EA= OR 2.59 (95% CI 1.42-4.72). Both approaches also observed positive associations with ketone esters and fuels & petroleum-based solvents.
CONCLUSION
The results suggest that some organic solvents might be involved in the pathogenesis of TGCT among occupationally exposed men. The combined use of JEM+SQ+EA seemed to limit misclassification by considering individual exposure variability and is, therefore, an appealing approach to assess occupational exposures in epidemiological studies.
期刊介绍:
The aim of the Journal is to promote research in the fields of occupational and environmental health and safety and to increase knowledge through the publication of original research articles, systematic reviews, and other information of high interest. Areas of interest include occupational and environmental epidemiology, occupational and environmental medicine, psychosocial factors at work, physical work load, physical activity work-related mental and musculoskeletal problems, aging, work ability and return to work, working hours and health, occupational hygiene and toxicology, work safety and injury epidemiology as well as occupational health services. In addition to observational studies, quasi-experimental and intervention studies are welcome as well as methodological papers, occupational cohort profiles, and studies associated with economic evaluation. The Journal also publishes short communications, case reports, commentaries, discussion papers, clinical questions, consensus reports, meeting reports, other reports, book reviews, news, and announcements (jobs, courses, events etc).