抗氧化剂在肥胖症和糖尿病中作为免疫促进剂的作用:从神经胶质病变角度的系统综述

L. Sharma, Dhananjay Sharma
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摘要

研究背景本研究的主要目的是进行系统性文献综述,研究抗氧化剂在肥胖症和糖尿病中的有益作用,以及抗氧化剂在神经胶质病变和肠道微生物组对抗氧化剂产生和肠道神经系统(ENS)保护的关联:于 2022 年 6 月 8 日在 Google Scholar 和 PubMed 数据库中进行了电子文献检索,查阅了所有以英文发表的文章。研究不受限制(地区或任何时间范围)。研究包括以人为对象的随机对照试验(RCT)和观察性研究,主要关注体重变化、体重指数(BMI)、腰围身高比(WHTR)、腰围臀围比(WHR)、空腹血糖水平、糖化血红蛋白(HbA1c)等与糖尿病和肥胖有关的参数。此外,还对神经胶质病变和肠道微生物组进行了搜索:开始的数据库搜索共筛选出 2428 篇文章,其中 1310 篇来自 PubMed,876 篇来自 Google Scholar,242 篇来自其他来源。去除重复文章后,共找到 2,040 篇文章(重复文章总数为 388 篇),阅读标题和摘要后,全文文章进一步减少到 139 篇。对这 139 篇研究进行了全文分析,结果排除了 123 篇研究,最后纳入 16 篇文章进行系统分析:对现有研究的文献检索表明,肥胖和糖尿病神经胶质病变之间存在抗氧化剂摄入量的相互联系。研究结果表明,肥胖和糖尿病患者的抗氧化剂含量都很低,尤其是类胡萝卜素、视黄醇、抗坏血酸、生育酚、镁和锌。虽然有少数研究表明,与正常体重人群相比,糖尿病和肥胖受试者的上述抗氧化剂摄入量较低,但这并不是每项研究都认可的。
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Role of antioxidants as immunity booster in obesity and diabetes: a systematic review on neuro-gliopathies perspective
Background: The main objective of the study was to carry out a systematic literature review to investigate the beneficial role of antioxidants in obesity and diabetes and the association of antioxidants in neuro-gliopathies and gut microbiome on antioxidant production and enteric nervous system (ENS) protection. Methods: A literature search was done electronically on 8 June 2022 in the databases Google Scholar, and PubMed, reviewing all the articles published in English. There were no limitations for the study (region, or any time frame). The study included randomized controlled trials (RCTs) and observational studies on a human subject, primarily focusing on information such as a change in body weight, body mass index (BMI), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), fasting blood glucose level, glycated haemoglobin (HbA1c), and other parameters that connected with diabetes and obesity. The search was also conducted for neuro-gliopathies and gut microbiome. Results: The beginning database search picked out a total of 2,428 articles, 1,310 in PubMed, 876 in Google Scholar, and 242 records from other sources. A total of 2,040 (total duplicates 388) was found after removing the duplicated articles, and after reading the title and abstracts were further decreased to 139 full-text articles. These 139 studies went for full-text analysis, which resulted in the exclusion of 123 studies and generated a final 16 articles included for systemic analysis. Discussion: This literature search of present studies shows the interconnection between antioxidant intake among obese and diabetes neuro-gliopathies. The findings indicate both obese and diabetic patients have a minimum content of antioxidants, especially carotenoids, retinol, ascorbic acid, tocopherol, magnesium, and zinc. While few research illustrated that ingestion of the abovementioned antioxidants was lowered among diabetes and obese subjects in contrast with their normal-weight population, this was not endorsed by every study.
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