Mavacamten:肥厚型心肌病新型治疗方法综述

Ayesha Abdul Qadir Memon, Areeba Shamim, Sanoober Mirza, Muhammad Osama, Iyad Naeem Muhammad, Calvin R Wei
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摘要

肥厚型心肌病(HCM)是一种可导致左心室肥厚、心律失常、心力衰竭和心脏性猝死的心脏病。目前,药物治疗效果有限且不理想。Mavacamten(CamzyosTM)是一种心脏肌球蛋白抑制剂,可作为降低心肌收缩力和恢复心肌功能的治疗选择。美国食品和药物管理局(FDA)于 2022 年批准使用 Mavacamten 治疗 HCM 症状。临床研究证明,Mavacamten 可减少左室流出道(LVOT)受累、心脏过度收缩和肥厚。本综述概述了 HCM、其病理生理学、目前的治疗方法、Mavacamten 的合成以及 Mavacamten 的临床试验。
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Mavacamten: A Review of a Novel Therapeutic Approach for Hypertrophic Cardiomyopathy.
Hypertrophic Cardiomyopathy (HCM) is a heart disease that can cause left ventricular hypertrophy, arrhythmias, heart failure, and sudden cardiac death. Currently, pharmacological treatment is limited and ineffective. Mavacamten (CamzyosTM) is a cardiac myosin inhibitor developed as a therapeutic option to reduce myocardial contractility and restoration of myocardial function. The Food and Drug Administration (FDA) approved the use of Mavacamten in 2022 for HCM symptoms. Clinical studies have proven that Mavacamten can reduce Left Ventricular Outflow Tract (LVOT) involvement, cardiac hypercontraction, and hypertrophy. This review provides an overview of HCM, its pathophysiology, current treatments, synthesis of Mavacamten, and the clinical trials of Mavacamten.
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