奶山羊乳房内注射长效头孢匹林和氯唑西林的药代动力学。

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY Journal of veterinary pharmacology and therapeutics Pub Date : 2024-04-04 DOI:10.1111/jvp.13445
Michelle P. Buckley, Kristen P. Hayman, Laura Burns, Dwayne Schrunk, Patrick J. Gorden
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引用次数: 0

摘要

确定山羊乳房内抗菌药的药代动力学有助于预测适当的停肉和停奶时间间隔,这些药物可有效治疗干奶期由非金黄色葡萄球菌引起的亚临床乳腺炎。24 头健康的泌乳母山羊参加了这项研究。一半的母鹿通过乳房内输注的方式在乳房两侧各注射了 300 毫克的苄星头孢匹林(ToMORROW,勃林格殷格翰兽医公司,德卢斯,佐治亚州)。其余的母牛每半边乳房注射 500 毫克氯唑西林苄星青霉素(Orbenin DC,默克公司,新泽西州拉威)。在治疗前和治疗后 7 天收集血浆,然后通过液相色谱法和串联质谱法进行分析。药代动力学参数是通过商用软件(MonolixSuite)采用非室方法测定的。给药后 7.06 小时(Tmax),头孢匹林的平均最大浓度(Cmax)为 0.073 μg/mL。基于最终采样点的血浆浓度曲线下面积(AUClast)为 1.06 h × μg/mL。在 CLOX 试验中,Cmax 为 0.074 μg/mL,Tmax 为 18 h,AUClast 为 5.尽管两种产品都使用苄星盐配制,但在药代动力学参数(包括 AUC、T1/2 和 MRTlast)方面存在明显差异。这些数据将用于规划两种产品的牛奶和组织残留消耗研究的采样计划。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Pharmacokinetics of long-acting cephapirin and cloxacillin after intramammary administration in dairy goats

Determining the pharmacokinetics of intramammary antimicrobials in goats can assist in predicting appropriate meat and milk withdrawal intervals for drugs that are effective at treating subclinical mastitis due to non-aureus Staphylococci during the dry period. Twenty-four healthy, lactating does were enrolled in this study. Half were administered 300 mg of cephapirin benzathine (ToMORROW, Boehringer Ingelheim Vetmedica, Duluth, GA) via intramammary infusion into each half of the udder. The remaining does had 500 mg cloxacillin benzathine (Orbenin DC, Merck & Co., Rahway, NJ) administered per half. Plasma was collected before treatment and for 7 days post-treatment followed by analysis via liquid chromatography with tandem mass spectroscopy. Pharmacokinetic parameters were determined using noncompartmental methods via commercial software (MonolixSuite). The mean maximum concentration (C max) of cephapirin of 0.073 μg/mL was noted at 7.06 h post-administration (T max). The area under the plasma concentration curve based on the final sampling point (AUClast) was 1.06 h × μg/mL. The mean residence time until the final sampling point (MRTlast) was 13.55 h. Mean terminal half-life (T ½) of cephapirin was 6.98 h. In CLOX does, C max was 0.074 μg/mL with a T max of 18 h, AUClast was 5.71 h × μg/mL, T ½ was 77.45 h, and MRTlast was 65.36 h. Despite both products being formulated with benzathine salts, marked differences were noted in pharmacokinetic parameters including AUC, T 1/2, and MRTlast. This data will be used to plan sampling schedules for milk and tissue residue depletion studies for both products.

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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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