Philip Drake, Ali Algaddafi, Thomas Swift, R. Abd‐Alhameed
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引用次数: 0
摘要
磁场热疗是一种通过交变磁场(AMF)提高局部温度来治疗肿瘤的技术,交变磁场由磁性纳米粒子(MNPs)介导。在交变磁场中,这些粒子升温并杀死细胞。交变磁场与加热速率之间的关系非常复杂,导致在比较不同 MNP 和交变磁场条件下的数据时出现混淆。这项研究可以在保持其他参数不变的情况下,以多种 AMF 振幅监测热反应。基于零电压-零电流(ZVZC)谐振电路设计了一个感应加热线圈。线圈工作频率为 93 kHz,直流驱动电压可变(12-30 V)。使用 NEC4 软件建立磁场分布模型,并通过共沉淀法合成 MNPs。磁场在线圈中心是均匀的,范围从 1 kAm-1 到 12 kAm-1,取决于直流驱动电压。在 93 kHz 和 2.1 kAm-1 和 12.6 kAm-1 频率下,MNPs 的比吸收率(SAR)分别为 1.37 Wg-1[Fe] 和 6.13 Wg-1[Fe]。测得的 SAR 值与频率和场强的乘积(SARα f Ho)成正比。因此,建议在比较各组数据时,应根据这一关系对 SAR 值进行归一化处理,而不是使用更常见的基于场强平方的关系(SARα f Ho2)。
Design and Modelling of an Induction Heating Coil to Investigate the Thermal Response of Magnetic Nanoparticles for Hyperthermia Applications
Magnetic Field Hyperthermia is a technique where tumours are treated through an increase in local temperature upon exposure to alternating magnetic fields (AMFs) that are mediated by magnetic nano-particles (MNPs). In an AMF, these particles heat-up and kill the cells. The relationship between an AMF and the heating-rate is complex, leading to confusion when comparing data for different MNP and AMF conditions. This work allows for the thermal-response to be monitored at multiple AMF amplitudes while keeping other parameters constant. An induction-heating coil was designed based on a Zero-Voltage-Zero-Current (ZVZC) resonant circuit. The coil operates at 93 kHz with a variable DC drive-voltage (12–30 V). NEC4 software was used to model the magnetic field distribution, and MNPs were synthesised by the coprecipitation method. The magnetic field was found to be uniform at the centre of the coil and ranged from 1 kAm−1 to 12 kAm−1, depending on the DC drive-voltage. The MNPs were found to have a specific absorption rate (SAR) of 1.37 Wg−1[Fe] and 6.13 Wg−1[Fe] at 93 kHz and 2.1 kAm−1 and 12.6 kAm−1, respectively. The measured SAR value was found to be directly proportional to the product of the frequency and field-strength (SARα f Ho). This leads to the recommendation that, when comparing data from various groups, the SAR value should be normalized following this relationship and not using the more common relationship based on the square of the field intensity (SARα f Ho2).