Y. Ge, Qian You, Feng Gao, Gang Liu, Ling Wang, Bo Li, M. Tian, Minghui Yang, Xinbao Wu
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The CT scans provided data on cross-sectional area and attenuation for the gluteus maximus (G.MaxM) and the combined gluteus medius and minimus (G.Med/MinM). Participants were categorized into CI and non-CI groups based on education levels and MMSE scores. Multivariate logistic regressions, propensity score (PS) methods, and subgroup analysis were employed to analyze associations and validate findings. This study included 123 participants (81.6 ± 6.8 years, 74% female) with CI and 556 participants (78.5 ± 7.7 years, 72% female) without. Compared to the non-CI group, muscle parameters, especially density, were significantly lower in the CI group. Specifically, G.Med/Min muscle density, but not size was robustly associated with CI (odds ratio (OR) = 0.77, 95% confidence interval = 0.62–0.96, P = 0.02), independent of other medical situations. Sensitivity analysis corroborated that G.Med/Min muscle density was consistently lower in the CI group than the non-CI group, as evidenced in the PS matched (P = 0.024) and weighted cohort (P = 0.033). Enhanced muscle parameters, particularly muscle density in the G.Med/MinM muscle, correlate with a lower risk of CI. Muscle density demonstrates a stronger association with cognitive performance than muscle size, highlighting its potential as a key focus in future cognitive health research.","PeriodicalId":14611,"journal":{"name":"JBMR Plus","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Muscle density, but not size, is independently associated with cognitive health in older adults with hip fractures\",\"authors\":\"Y. Ge, Qian You, Feng Gao, Gang Liu, Ling Wang, Bo Li, M. 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引用次数: 0
摘要
摘要 新的证据表明,骨骼肌与认知功能之间存在复杂的相互作用。尽管通过计算机断层扫描(CT)可以测量出肌肉数量和质量之间的已知差异,但它们与认知能力之间关系的确切性质仍未得到充分探讨。为了研究髋部骨折老年人的肌肉大小和密度与认知障碍(CI)之间的联系,我们在一项前瞻性队列研究中对 679 名 65 岁以上的髋部骨折患者进行了交叉分析。我们利用小型精神状态检查(MMSE)和常规髋部 CT 成像来评估髋部骨折老年人的认知功能和肌肉特征。CT 扫描提供了臀大肌(G.MaxM)以及臀中肌和臀小肌(G.Med/MinM)的横截面积和衰减数据。根据受教育程度和 MMSE 评分将参与者分为 CI 组和非 CI 组。研究采用多变量逻辑回归、倾向得分(PS)方法和亚组分析来分析相关性并验证研究结果。该研究包括 123 名 CI 患者(81.6 ± 6.8 岁,74% 为女性)和 556 名非 CI 患者(78.5 ± 7.7 岁,72% 为女性)。与非 CI 组相比,CI 组的肌肉参数(尤其是密度)明显较低。具体来说,G.Med/Min肌肉密度与CI密切相关(几率比(OR)=0.77,95%置信区间=0.62-0.96,P=0.02),但与体型无关,与其他医疗情况也无关。敏感性分析证实,CI 组的 G.Med/Min 肌肉密度一直低于非 CI 组,这一点在 PS 匹配组(P = 0.024)和加权组群(P = 0.033)中得到了证实。增强的肌肉参数,尤其是 G.Med/MinM 肌肉的肌肉密度,与较低的 CI 风险相关。肌肉密度与认知能力的关系比肌肉大小更密切,这表明肌肉密度有可能成为未来认知健康研究的重点。
Muscle density, but not size, is independently associated with cognitive health in older adults with hip fractures
Abstract Emerging evidence indicates a complex interplay between skeletal muscle and cognitive function. Despite the known differences between muscle quantity and quality, which can be measured via computed tomography (CT), the precise nature of their associations with cognitive performance remain underexplored. To investigate the links between muscle size and density and cognitive impairment (CI) in the older adults with hip fractures, we conducted a post hoc, cross-sectional analysis within a prospective cohort study on 679 patients with hip fractures over 65. Mini-Mental State Examination (MMSE) and routine hip CT imaging were utilized to assess cognition function and muscle characteristics in older adults with hip fractures. The CT scans provided data on cross-sectional area and attenuation for the gluteus maximus (G.MaxM) and the combined gluteus medius and minimus (G.Med/MinM). Participants were categorized into CI and non-CI groups based on education levels and MMSE scores. Multivariate logistic regressions, propensity score (PS) methods, and subgroup analysis were employed to analyze associations and validate findings. This study included 123 participants (81.6 ± 6.8 years, 74% female) with CI and 556 participants (78.5 ± 7.7 years, 72% female) without. Compared to the non-CI group, muscle parameters, especially density, were significantly lower in the CI group. Specifically, G.Med/Min muscle density, but not size was robustly associated with CI (odds ratio (OR) = 0.77, 95% confidence interval = 0.62–0.96, P = 0.02), independent of other medical situations. Sensitivity analysis corroborated that G.Med/Min muscle density was consistently lower in the CI group than the non-CI group, as evidenced in the PS matched (P = 0.024) and weighted cohort (P = 0.033). Enhanced muscle parameters, particularly muscle density in the G.Med/MinM muscle, correlate with a lower risk of CI. Muscle density demonstrates a stronger association with cognitive performance than muscle size, highlighting its potential as a key focus in future cognitive health research.