Simultaneous Liver Kidney Transplantation in a Primary Type 2 Hyperoxaluria With Corrected TOF and Severe Cardiomyopathy: A Case Report

Background

Primary type 2 hyperoxaluria is a very rare genetic disorder,^1,2 where in the progression to renal failure was assumed to be insidious and not very common.³ PH2 is due to deficient glyoxylate reductase/hydroxypyruvate reductase (GRHPR),^1,2 which was thought to have extra-hepatic production also.⁴ The progression to renal failure in these patient subgroups is well documented in the Literature and the role of SLK (simultaneous liver and kidney transplantation) has not been clearly established.⁸

Method

We present a case report of a young girl with PH2, who successfully underwent SLK, with evidence of reduction in the urine oxalate levels post SLK.

Results

PH2, though a rare genetic disease, has a proven potential to progress to chronic renal failure requiring transplantation, renal transplantation alone has not shown any benefit, these patients can be offered SLK as a primary treatment option, to improve the outcomes, this needs further validation with consensus and studies.