糖尿病患者和非糖尿病患者 HbA1c 水平的季节性变化

IF 1.7 Q3 MEDICAL LABORATORY TECHNOLOGY Practical Laboratory Medicine Pub Date : 2024-05-01 DOI:10.1016/j.plabm.2024.e00396
Sana Ahuja , Sugandha Sugandha , Rohit Kumar , Sufian Zaheer , Mukul Singh
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引用次数: 0

摘要

背景血红蛋白 A1c(HbA1c)是长期血糖控制的关键指标。糖尿病控制与并发症试验(DCCT)确定了其相关性,但在了解糖尿病患者 HbA1c 水平的潜在季节性变化方面仍存在差距。本研究强调了探索 HbA1c 水平潜在季节性变化及其对糖尿病患者影响的必要性。材料和方法这是一项观察性研究,于 2019 年 1 月至 12 月在一家三级医院进行,研究分析了 8138 名患者的 HbA1c 水平。使用含 EDTA 钾的血瓶采集血样,并用自动分析仪进行处理。结果 平均 HbA1c 水平在季风季节(6 月至 9 月)达到峰值,在秋季(10 月至 11 月)最低。亚组分析显示,HbA1c 值低于 6.5 % 和高于 6.5 % 的患者之间存在差异。血糖得到控制的患者在冬季(12 月至次年 2 月)和季风季节(6 月至 9 月)的血糖水平较高,而 HbA1c 值≥ 6.5 % 的患者在季风季节(6 月至 9 月)和秋季(10 月至 11 月)的血糖水平明显低于夏季(3 月至 5 月)。季风季节(6 月至 9 月)的 HbA1c 水平最高,这可能与户外活动减少和饮食变化有关。这项研究强调,有必要考虑季节性影响因素,对糖尿病进行有针对性的管理。建议在印度不同地区进一步开展广泛的纵向研究,以全面掌握季节变化对糖尿病结果的影响。
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Seasonal variation of HbA1c levels in diabetic and non-diabetic patients

Background

Hemoglobin A1c (HbA1c) serves as a pivotal marker for long-term glycemic control. The Diabetes Control and Complications Trial (DCCT) established its relevance, yet gaps exist in understanding potential seasonal variations in HbA1c levels among diabetic patients. The study highlights the need to explore potential seasonal variations in HbA1c levels and their impact on diabetic patients.

Materials and methods

This is an observational study conducted in a tertiary care hospital from January to December 2019, the study analyzed HbA1c levels in 8138 patients. Blood samples were collected using Potassium EDTA-containing vials and processed with an automated analyzer. Seasonal variations were explored using time series analysis.

Results

Mean HbA1c levels peaked during the monsoon (June to September) and were lowest in autumn (October to November). Subgroup analysis revealed differences in patients with HbA1c values below and above 6.5 %. Those with controlled blood sugar showed higher levels in winter (December to February) and monsoon (June to September), while patients with HbA1c values ≥ 6.5 % exhibited significantly lower levels in monsoon (June to September) and autumn (October to November) compared to summer (March to May).

Conclusion

In contrast to global trends, Indian patients demonstrated distinct seasonal variations in HbA1c levels. The highest levels during the monsoon (June to September) may be linked to reduced outdoor activity and dietary changes. The study emphasizes the need for tailored diabetes management considering seasonal influences. Further extensive, longitudinal studies across diverse Indian regions are recommended to comprehensively grasp the impact of seasonal changes on diabetes outcomes.

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来源期刊
Practical Laboratory Medicine
Practical Laboratory Medicine Health Professions-Radiological and Ultrasound Technology
CiteScore
3.50
自引率
0.00%
发文量
40
审稿时长
7 weeks
期刊介绍: Practical Laboratory Medicine is a high-quality, peer-reviewed, international open-access journal publishing original research, new methods and critical evaluations, case reports and short papers in the fields of clinical chemistry and laboratory medicine. The objective of the journal is to provide practical information of immediate relevance to workers in clinical laboratories. The primary scope of the journal covers clinical chemistry, hematology, molecular biology and genetics relevant to laboratory medicine, microbiology, immunology, therapeutic drug monitoring and toxicology, laboratory management and informatics. We welcome papers which describe critical evaluations of biomarkers and their role in the diagnosis and treatment of clinically significant disease, validation of commercial and in-house IVD methods, method comparisons, interference reports, the development of new reagents and reference materials, reference range studies and regulatory compliance reports. Manuscripts describing the development of new methods applicable to laboratory medicine (including point-of-care testing) are particularly encouraged, even if preliminary or small scale.
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