对雷博替尼耐药的L2086F突变ROS1重排NSCLC对卡博替尼有反应：一份病例报告

IF 3 Q2 ONCOLOGY JTO Clinical and Research Reports Pub Date : 2024-07-01 DOI:10.1016/j.jtocrr.2024.100673

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引用次数: 0

摘要

Repotrectinib于2023年11月获得许可，是一种新型ROS1酪氨酸激酶抑制剂（TKI），对G2032R具有活性，G2032R是前几代ROS1 TKIs最常见的耐药突变。在此，我们报告了一例接受过大量预处理的晚期L1951R和L2026M突变ROS1重排NSCLC患者，该患者最初对repotrectinib有反应，但后来随着L2086F突变的出现进一步产生了靶向耐药。随后，该患者对卡博替尼（一种针对 L2086F 具有临床前活性的独立 ROS1 TKI）产生了反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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L2086F Mutant ROS1-Rearranged NSCLC Resistant to Repotrectinib Responds to Cabozantinib: A Case Report

Repotrectinib, licensed in November 2023, is a novel ROS1 tyrosine kinase inhibitor (TKI) with activity against G2032R, the most common resistance mutation to prior generations of ROS1 TKIs. Here, we report a case of a patient who was heavily pretreated, with advanced L1951R and L2026M mutated ROS1-rearranged NSCLC, who initially responded to repotrectinib but later developed further on-target resistance with the emergence of an L2086F mutation. The disease then responded to cabozantinib, a separate class of ROS1 TKI with preclinical activity against L2086F.

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