{"title":"脑梗塞后早期有害的抗炎巨噬细胞招募","authors":"Alexandre Paccalet PhD , Sally Badawi PhD , Bruno Pillot PhD , Lionel Augeul MRes , Laura Mechtouff MD, PhD , Zeina Harhous PhD , Yves Gouriou AP, PhD , Mélanie Paillard PhD , Marine Breuilly PhD , Camille Amaz MsRes , Yvonne Varillon MsRes , Simon Leboube MD , Camille Brun MsRes , Cyril Prieur MD, PhD , Gilles Rioufol MD, PhD , Nathan Mewton MD, PhD , Michel Ovize MD, PhD , Gabriel Bidaux PhD , Thomas Bochaton MD, PhD , Claire Crola Da Silva PhD","doi":"10.1016/j.jacbts.2024.01.019","DOIUrl":null,"url":null,"abstract":"<div><p>Using a translational approach with an ST-segment myocardial infarction (STEMI) cohort and mouse model of myocardial infarction, we highlighted the role of the secreted IL-6 and MCP-1 cytokines and the STAT3 pathway in heart macrophage recruitment and activation. Cardiac myocytes secrete IL-6 and MCP-1 in response to hypoxic stress, leading to a recruitment and/or polarization of anti-inflammatory macrophages via the STAT3 pathway. In our preclinical model of myocardial infarction, neutralization of IL-6 and MCP-1 or STAT3 pathway reduced infarct size. Together, our data demonstrate that anti-inflammatory macrophages can be deleterious in the acute phase of STEMI.</p></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 5","pages":"Pages 593-604"},"PeriodicalIF":8.4000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452302X24000536/pdfft?md5=fea6bc8688d7a0ee7a08b3b71e733f77&pid=1-s2.0-S2452302X24000536-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase\",\"authors\":\"Alexandre Paccalet PhD , Sally Badawi PhD , Bruno Pillot PhD , Lionel Augeul MRes , Laura Mechtouff MD, PhD , Zeina Harhous PhD , Yves Gouriou AP, PhD , Mélanie Paillard PhD , Marine Breuilly PhD , Camille Amaz MsRes , Yvonne Varillon MsRes , Simon Leboube MD , Camille Brun MsRes , Cyril Prieur MD, PhD , Gilles Rioufol MD, PhD , Nathan Mewton MD, PhD , Michel Ovize MD, PhD , Gabriel Bidaux PhD , Thomas Bochaton MD, PhD , Claire Crola Da Silva PhD\",\"doi\":\"10.1016/j.jacbts.2024.01.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Using a translational approach with an ST-segment myocardial infarction (STEMI) cohort and mouse model of myocardial infarction, we highlighted the role of the secreted IL-6 and MCP-1 cytokines and the STAT3 pathway in heart macrophage recruitment and activation. Cardiac myocytes secrete IL-6 and MCP-1 in response to hypoxic stress, leading to a recruitment and/or polarization of anti-inflammatory macrophages via the STAT3 pathway. In our preclinical model of myocardial infarction, neutralization of IL-6 and MCP-1 or STAT3 pathway reduced infarct size. Together, our data demonstrate that anti-inflammatory macrophages can be deleterious in the acute phase of STEMI.</p></div>\",\"PeriodicalId\":14831,\"journal\":{\"name\":\"JACC: Basic to Translational Science\",\"volume\":\"9 5\",\"pages\":\"Pages 593-604\"},\"PeriodicalIF\":8.4000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2452302X24000536/pdfft?md5=fea6bc8688d7a0ee7a08b3b71e733f77&pid=1-s2.0-S2452302X24000536-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JACC: Basic to Translational Science\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2452302X24000536\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JACC: Basic to Translational Science","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452302X24000536","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase
Using a translational approach with an ST-segment myocardial infarction (STEMI) cohort and mouse model of myocardial infarction, we highlighted the role of the secreted IL-6 and MCP-1 cytokines and the STAT3 pathway in heart macrophage recruitment and activation. Cardiac myocytes secrete IL-6 and MCP-1 in response to hypoxic stress, leading to a recruitment and/or polarization of anti-inflammatory macrophages via the STAT3 pathway. In our preclinical model of myocardial infarction, neutralization of IL-6 and MCP-1 or STAT3 pathway reduced infarct size. Together, our data demonstrate that anti-inflammatory macrophages can be deleterious in the acute phase of STEMI.
期刊介绍：
JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.
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