{"title":"世卫组织真菌优先病原体清单:审查优先次序的关键性重新评估。","authors":"Giacomo Casalini MD , Andrea Giacomelli MD , Prof Spinello Antinori PhD","doi":"10.1016/S2666-5247(24)00042-9","DOIUrl":null,"url":null,"abstract":"<div><p>In October, 2022, WHO published the first fungal priority pathogen list, which categorised 19 fungal entities into three priority groups (critical, high, and medium), for prioritisation of research efforts. The final ranking was determined via multiple criteria decision analysis, considering both research and development needs and perceived public health importance. In this Personal View, we discuss the positioning of the fungal pathogens, namely, Mucorales, <em>Candida</em> spp, <em>Histoplasma</em> spp, <em>Coccidioides</em> and <em>Paracoccidioides</em> spp, <em>Fusarium</em> spp, eumycetoma causative agents, <em>Talaromyces marneffei</em>, and <em>Pneumocystis jirovecii</em>, while expressing concerns about potential disparities between the WHO fungal priority pathogen list ranking and the actual disease burden associated with these pathogens. Finally, we propose a revised prioritisation list that also considers the regional disparities in the burden of fungal diseases.</p></div>","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":null,"pages":null},"PeriodicalIF":20.9000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666524724000429/pdfft?md5=0c9f8fbc91e25678c968c4dbe0f721a0&pid=1-s2.0-S2666524724000429-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The WHO fungal priority pathogens list: a crucial reappraisal to review the prioritisation\",\"authors\":\"Giacomo Casalini MD , Andrea Giacomelli MD , Prof Spinello Antinori PhD\",\"doi\":\"10.1016/S2666-5247(24)00042-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In October, 2022, WHO published the first fungal priority pathogen list, which categorised 19 fungal entities into three priority groups (critical, high, and medium), for prioritisation of research efforts. The final ranking was determined via multiple criteria decision analysis, considering both research and development needs and perceived public health importance. In this Personal View, we discuss the positioning of the fungal pathogens, namely, Mucorales, <em>Candida</em> spp, <em>Histoplasma</em> spp, <em>Coccidioides</em> and <em>Paracoccidioides</em> spp, <em>Fusarium</em> spp, eumycetoma causative agents, <em>Talaromyces marneffei</em>, and <em>Pneumocystis jirovecii</em>, while expressing concerns about potential disparities between the WHO fungal priority pathogen list ranking and the actual disease burden associated with these pathogens. Finally, we propose a revised prioritisation list that also considers the regional disparities in the burden of fungal diseases.</p></div>\",\"PeriodicalId\":46633,\"journal\":{\"name\":\"Lancet Microbe\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":20.9000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666524724000429/pdfft?md5=0c9f8fbc91e25678c968c4dbe0f721a0&pid=1-s2.0-S2666524724000429-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lancet Microbe\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666524724000429\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lancet Microbe","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666524724000429","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
The WHO fungal priority pathogens list: a crucial reappraisal to review the prioritisation
In October, 2022, WHO published the first fungal priority pathogen list, which categorised 19 fungal entities into three priority groups (critical, high, and medium), for prioritisation of research efforts. The final ranking was determined via multiple criteria decision analysis, considering both research and development needs and perceived public health importance. In this Personal View, we discuss the positioning of the fungal pathogens, namely, Mucorales, Candida spp, Histoplasma spp, Coccidioides and Paracoccidioides spp, Fusarium spp, eumycetoma causative agents, Talaromyces marneffei, and Pneumocystis jirovecii, while expressing concerns about potential disparities between the WHO fungal priority pathogen list ranking and the actual disease burden associated with these pathogens. Finally, we propose a revised prioritisation list that also considers the regional disparities in the burden of fungal diseases.
期刊介绍:
The Lancet Microbe is a gold open access journal committed to publishing content relevant to clinical microbiologists worldwide, with a focus on studies that advance clinical understanding, challenge the status quo, and advocate change in health policy.