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引用次数: 0
摘要
气管插管在创伤点护理和急诊医学中具有重要意义。然而，在插管过程中，喉粘膜和插管之间的摩擦可能会导致喉损伤和随后的慢性并发症。在此，我们介绍一种基于透明质酸的润滑涂层。受贻贝的启发，我们首先将透明质酸与多巴胺共轭，得到 HD，然后将三嵌段共聚物 Pluronic F127（F127）与 HD 复配，形成胶束层。在弱碱性条件下，多巴胺可以帮助涂层在管材上沉积，同时提高涂层的稳定性。F127 和 HD 形成的胶束层具有优异的保水和润滑性能。经摩擦性能测试，HD-F127 涂层的摩擦系数比对照组低 56%。
Coatings based on dopamine-modified hyaluronic acid and Pluronic F127 for tracheal intubation
Endotracheal intubation holds significant importance in trauma point care and emergency medicine. However, laryngeal injury and subsequent chronic complications can result from the friction between the mucosa and the tube during intubation. Here we present a lubricant coating based on hyaluronic acid. Inspired by mussels, hyaluronic acid was first conjugated with dopamine to obtain HD, and then a triblock copolymer Pluronic F127 (F127) was complexed with HD to form a micelle layer. Dopamine can assist coating deposition on the tube under weak alkaline conditions, while improving the coating stability. The micelle layer formed by F127 and HD provides excellent water retention and lubrication performance. The friction coefficient of the HD-F127 coating was 56% lower than that of the control, as determined by a friction performance test.
期刊介绍：
Australian Journal of Chemistry - an International Journal for Chemical Science publishes research papers from all fields of chemical science. Papers that are multidisciplinary or address new or emerging areas of chemistry are particularly encouraged. Thus, the scope is dynamic. It includes (but is not limited to) synthesis, structure, new materials, macromolecules and polymers, supramolecular chemistry, analytical and environmental chemistry, natural products, biological and medicinal chemistry, nanotechnology, and surface chemistry.
Australian Journal of Chemistry is published with the endorsement of the Commonwealth Scientific and Industrial Research Organisation (CSIRO) and the Australian Academy of Science.
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