{"title":"前瞻性试验研究:在立体定向体放射治疗 (SBRT) 和卡铂化疗前后,利用连续氟-18-脱氧葡萄糖(18F-FDG)正电子发射断层扫描-计算机断层扫描 (PET/CT) 获得的定量值变化,对患有阑尾骨肉瘤的狗的生存率和疗效进行评估","authors":"Tiffany W. Martin, Lynn Griffin","doi":"10.1111/vru.13361","DOIUrl":null,"url":null,"abstract":"Serial fluorine 18 fluorodeoxyglucose (<jats:sup>18</jats:sup>F‐FDG) positron emission tomography–CT (PET/CT) is commonly used in human oncology to prognosticate and evaluate for therapeutic effectiveness. In this pilot study, dogs with naturally occurring appendicular osteosarcoma were evaluated with serial <jats:sup>18</jats:sup>F‐FDG PET/CT in an attempt to assess for response to therapy, prognostic factors, and appropriateness of imaging intervals. Fourteen dogs were enrolled in the trial. All dogs had the initial <jats:sup>18</jats:sup>F‐FDG PET/CT (PET1), with nine dogs having their end‐of‐therapy <jats:sup>18</jats:sup>F‐FDG PET/CT (EoT PET) 3 months after stereotactic body radiation therapy (SBRT) to the primary tumor. The median percent change from the PET1 to the EoT PET for the standard uptake value maximum (SUV<jats:sub>max%</jats:sub>) was −58% (range: −17 to −88%), metabolic tumor volume (MTV<jats:sub>%</jats:sub>) was −99.8% (range: −65 to −100%), and total lesion glycolysis (TLG<jats:sub>%</jats:sub>) was −99.8% (range: −75 to −100%), all of which were significant (<jats:italic>P</jats:italic> < .05, <.05, and <.05, respectively). On evaluation, it was found that volumes of GTV and CTV were significant for survival (<jats:italic>P</jats:italic> < .05 and <.05), MTV<jats:sub>1</jats:sub>, TLG<jats:sub>1</jats:sub>, and SUV<jats:sub>max</jats:sub> on the EoT PET (SUV<jats:sub>maxEoT</jats:sub>) were predictive of metastasis (<jats:italic>P</jats:italic> < .05), and the SUV<jats:sub>max%</jats:sub> was significantly correlated to the time to first event (<jats:italic>P</jats:italic> < .05). Based on this data, serial <jats:sup>18</jats:sup>F‐FDG PET/CT performed 3 months after SBRT can show a significant reduction in avidity, and the quantitative data collected may help predict metastatic disease in canine appendicular osteosarcoma.","PeriodicalId":23581,"journal":{"name":"Veterinary Radiology & Ultrasound","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prospective pilot study utilizing changes in quantitative values obtained on serial fluorine‐18 fluorodeoxyglucose (18F‐FDG) positron emission tomography–computed tomography (PET/CT) in dogs with appendicular osteosarcoma before and after stereotactic body radiation therapy (SBRT) and carboplatin chemotherapy to assess for prediction of survival and therapeutic effectiveness\",\"authors\":\"Tiffany W. Martin, Lynn Griffin\",\"doi\":\"10.1111/vru.13361\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Serial fluorine 18 fluorodeoxyglucose (<jats:sup>18</jats:sup>F‐FDG) positron emission tomography–CT (PET/CT) is commonly used in human oncology to prognosticate and evaluate for therapeutic effectiveness. In this pilot study, dogs with naturally occurring appendicular osteosarcoma were evaluated with serial <jats:sup>18</jats:sup>F‐FDG PET/CT in an attempt to assess for response to therapy, prognostic factors, and appropriateness of imaging intervals. Fourteen dogs were enrolled in the trial. All dogs had the initial <jats:sup>18</jats:sup>F‐FDG PET/CT (PET1), with nine dogs having their end‐of‐therapy <jats:sup>18</jats:sup>F‐FDG PET/CT (EoT PET) 3 months after stereotactic body radiation therapy (SBRT) to the primary tumor. The median percent change from the PET1 to the EoT PET for the standard uptake value maximum (SUV<jats:sub>max%</jats:sub>) was −58% (range: −17 to −88%), metabolic tumor volume (MTV<jats:sub>%</jats:sub>) was −99.8% (range: −65 to −100%), and total lesion glycolysis (TLG<jats:sub>%</jats:sub>) was −99.8% (range: −75 to −100%), all of which were significant (<jats:italic>P</jats:italic> < .05, <.05, and <.05, respectively). On evaluation, it was found that volumes of GTV and CTV were significant for survival (<jats:italic>P</jats:italic> < .05 and <.05), MTV<jats:sub>1</jats:sub>, TLG<jats:sub>1</jats:sub>, and SUV<jats:sub>max</jats:sub> on the EoT PET (SUV<jats:sub>maxEoT</jats:sub>) were predictive of metastasis (<jats:italic>P</jats:italic> < .05), and the SUV<jats:sub>max%</jats:sub> was significantly correlated to the time to first event (<jats:italic>P</jats:italic> < .05). Based on this data, serial <jats:sup>18</jats:sup>F‐FDG PET/CT performed 3 months after SBRT can show a significant reduction in avidity, and the quantitative data collected may help predict metastatic disease in canine appendicular osteosarcoma.\",\"PeriodicalId\":23581,\"journal\":{\"name\":\"Veterinary Radiology & Ultrasound\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-04-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary Radiology & Ultrasound\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1111/vru.13361\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Radiology & Ultrasound","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/vru.13361","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Prospective pilot study utilizing changes in quantitative values obtained on serial fluorine‐18 fluorodeoxyglucose (18F‐FDG) positron emission tomography–computed tomography (PET/CT) in dogs with appendicular osteosarcoma before and after stereotactic body radiation therapy (SBRT) and carboplatin chemotherapy to assess for prediction of survival and therapeutic effectiveness
Serial fluorine 18 fluorodeoxyglucose (18F‐FDG) positron emission tomography–CT (PET/CT) is commonly used in human oncology to prognosticate and evaluate for therapeutic effectiveness. In this pilot study, dogs with naturally occurring appendicular osteosarcoma were evaluated with serial 18F‐FDG PET/CT in an attempt to assess for response to therapy, prognostic factors, and appropriateness of imaging intervals. Fourteen dogs were enrolled in the trial. All dogs had the initial 18F‐FDG PET/CT (PET1), with nine dogs having their end‐of‐therapy 18F‐FDG PET/CT (EoT PET) 3 months after stereotactic body radiation therapy (SBRT) to the primary tumor. The median percent change from the PET1 to the EoT PET for the standard uptake value maximum (SUVmax%) was −58% (range: −17 to −88%), metabolic tumor volume (MTV%) was −99.8% (range: −65 to −100%), and total lesion glycolysis (TLG%) was −99.8% (range: −75 to −100%), all of which were significant (P < .05, <.05, and <.05, respectively). On evaluation, it was found that volumes of GTV and CTV were significant for survival (P < .05 and <.05), MTV1, TLG1, and SUVmax on the EoT PET (SUVmaxEoT) were predictive of metastasis (P < .05), and the SUVmax% was significantly correlated to the time to first event (P < .05). Based on this data, serial 18F‐FDG PET/CT performed 3 months after SBRT can show a significant reduction in avidity, and the quantitative data collected may help predict metastatic disease in canine appendicular osteosarcoma.
期刊介绍:
Veterinary Radiology & Ultrasound is a bimonthly, international, peer-reviewed, research journal devoted to the fields of veterinary diagnostic imaging and radiation oncology. Established in 1958, it is owned by the American College of Veterinary Radiology and is also the official journal for six affiliate veterinary organizations. Veterinary Radiology & Ultrasound is represented on the International Committee of Medical Journal Editors, World Association of Medical Editors, and Committee on Publication Ethics.
The mission of Veterinary Radiology & Ultrasound is to serve as a leading resource for high quality articles that advance scientific knowledge and standards of clinical practice in the areas of veterinary diagnostic radiology, computed tomography, magnetic resonance imaging, ultrasonography, nuclear imaging, radiation oncology, and interventional radiology. Manuscript types include original investigations, imaging diagnosis reports, review articles, editorials and letters to the Editor. Acceptance criteria include originality, significance, quality, reader interest, composition and adherence to author guidelines.