壳聚糖涂层纳米粒子在创新型癌症生物医药中的应用

IF 3.5 4区 医学 Q2 CHEMISTRY, MEDICINAL Drug Development Research Pub Date : 2024-04-28 DOI:10.1002/ddr.22189
Niloufar Rezaei, Ibrahim Zarkesh, Alireza Fotouhi, Hani Keshavarz Alikhani, Moustapha Hassan, Massoud Vosough
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引用次数: 0

摘要

近十年来,纳米粒子(NPs)在癌症生物医学(包括研究、诊断和治疗)领域产生了巨大影响。然而,由于一些实际限制,它们的广泛应用仍然面临障碍,需要进一步开发。近来,人们对纳米颗粒的包覆层越来越感兴趣,以应对这些挑战。壳聚糖涂层纳米粒子生产简单、可生物降解、生物相容性好、具有抗菌活性和较低的细胞毒性。本研究全面概述了壳聚糖包衣 NPs 作为一类前景广阔的 NPs 在癌症生物医学中的应用。此外,我们还讨论了壳聚糖包覆脂质、金属和聚合物基纳米粒子在生物医学中的应用。此外,我们还综述了不同的涂层方法和生产/表征程序。此外,我们还强调了壳聚糖包衣 NPs 在生物和理化方面的优势,包括有利于控制释放、提高理化稳定性、改善细胞/组织相互作用以及提高药物的生物利用度。最后,讨论了壳聚糖包衣 NPs 在癌症生物医学中的应用前景。
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Chitosan-coated nanoparticles in innovative cancer bio-medicine

In the recent decade, nanoparticles (NPs) have had enormous implications in cancer biomedicine, including research, diagnosis, and therapy. However, their broad application still faces obstacles due to some practical limitations and requires further development. Recently, there has been more interest in the coated class of nanoparticles to address those challenges. Chitosan-coated NPs are simple to produce, biodegradable, biocompatible, exhibit antibacterial activity, and have less cytotoxicity. This study provides an updated and comprehensive overview of the application of chitosan-coated NPs as a promising class of NPs in cancer biomedicine. Additionally, we discussed chitosan-coated lipid, metal, and polymer-based nanoparticles in biomedical applications. Furthermore, different coating methods and production/characterization procedures were reviewed. Moreover, the biological and physicochemical advantages of chitosan-coated NPs, including facilitated controlled release, greater physicochemical stability, improved cell/tissue interaction, and enhanced bioavailability of medications, were highlighted. Finally, the prospects of chitosan-coated NPs in cancer biomedicine were discussed.

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来源期刊
CiteScore
6.40
自引率
2.60%
发文量
104
审稿时长
6-12 weeks
期刊介绍: Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on medicinal chemistry, pharmacology, biotechnology and biopharmaceuticals, toxicology, and drug delivery, formulation, and pharmacokinetics. The journal welcomes manuscripts on new compounds and technologies in all areas focused on human therapeutics, as well as global management, health care policy, and regulatory issues involving the drug discovery and development process. In addition to full-length articles, Drug Development Research publishes Brief Reports on important and timely new research findings, as well as in-depth review articles. The journal also features periodic special thematic issues devoted to specific compound classes, new technologies, and broad aspects of drug discovery and development.
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