Shuang He, Jin Tian, Jianhua Zang, Lin Long, Peng Liu, Yexi Zhang, Jun Xiao
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Analysis involved observing variations in the abundance, distribution, and composition of fecal intestinal microorganisms pretreatment and posttreatment via 16S rRNA gene sequencing.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>In this study involving 30 advanced lung adenocarcinoma patients, significant observations were made regarding the impact of immunotherapy on immune function and the gut microbiome composition. Patients were divided into treatment and control groups, revealing that immunotherapy led to a significant increase in CD4+ T cells and a decrease in CD8+ T cells among the treatment-responsive individuals, indicating an enhanced immune response. Furthermore, an in-depth analysis of the gut microbiome showed an increase in diversity and abundance of beneficial bacteria such as Faecalibacterium and Subdoligranulum in the treatment group. 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引用次数: 0
摘要
目的 本研究旨在探讨晚期不可切除肺腺癌患者在接受免疫疗法后肠道微生态和免疫功能的变化。 方法 30 例晚期不可切除肺腺癌患者接受了辛替利马单抗免疫疗法。四个治疗周期后,对疗效进行了评估,从而将患者分为两个不同的组群:对治疗有反应的组群和无反应的组群。分析包括通过 16S rRNA 基因测序观察治疗前和治疗后粪便肠道微生物的丰度、分布和组成变化。 结果 在这项涉及 30 名晚期肺腺癌患者的研究中,观察到了免疫疗法对免疫功能和肠道微生物组组成的重要影响。研究将患者分为治疗组和对照组,结果显示,免疫疗法使治疗反应组的 CD4+ T 细胞显著增加,CD8+ T 细胞减少,表明免疫反应增强。此外,对肠道微生物组的深入分析显示,治疗组中有益细菌(如粪便杆菌和亚多利格兰菌)的多样性和丰度均有所增加。这些发现凸显了免疫疗法在调节免疫功能和改变肠道微生物组多样性方面的双重作用,表明免疫疗法在改善晚期肺腺癌患者的健康状况方面具有潜在的治疗效果。 结论 肠道菌群的结构在增强抗肿瘤免疫疗法的疗效方面发挥着关键作用,突出了肠道微生态与免疫反应在癌症治疗结果中的相互作用。
Implications of intestinal microecology and immune function alterations for immunotherapy outcomes in advanced unresectable lung adenocarcinoma
Objective
This investigation aims to explore alterations in intestinal microecology and immune function among patients with advanced, unresectable lung adenocarcinoma undergoing different outcomes from immunotherapy.
Methods
A cohort of 30 patients diagnosed with advanced unresectable lung adenocarcinoma received sintilimab immunotherapy as a monotherapy. Post four treatment cycles, efficacy was assessed, leading to the segregation of patients into two distinct cohorts: those responsive to treatment and those nonresponsive. Analysis involved observing variations in the abundance, distribution, and composition of fecal intestinal microorganisms pretreatment and posttreatment via 16S rRNA gene sequencing.
Results
In this study involving 30 advanced lung adenocarcinoma patients, significant observations were made regarding the impact of immunotherapy on immune function and the gut microbiome composition. Patients were divided into treatment and control groups, revealing that immunotherapy led to a significant increase in CD4+ T cells and a decrease in CD8+ T cells among the treatment-responsive individuals, indicating an enhanced immune response. Furthermore, an in-depth analysis of the gut microbiome showed an increase in diversity and abundance of beneficial bacteria such as Faecalibacterium and Subdoligranulum in the treatment group. These findings highlight the dual effect of immunotherapy on modulating immune function and altering gut microbiome diversity, suggesting its potential therapeutic benefits in improving the health status of patients with advanced lung adenocarcinoma.
Conclusion
The structuring of gut flora plays a pivotal role in augmenting the efficacy of anti-tumor immunotherapy, underscoring the interplay between intestinal microecology and immune response in cancer treatment outcomes.
期刊介绍:
Overview
Effective with the 2016 volume, this journal will be published in an online-only format.
Aims and Scope
The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic.
We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including:
Asthma
Allergy
COPD
Non-invasive ventilation
Sleep related breathing disorders
Interstitial lung diseases
Lung cancer
Clinical genetics
Rhinitis
Airway and lung infection
Epidemiology
Pediatrics
CRJ provides a fast-track service for selected Phase II and Phase III trial studies.
Keywords
Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease,
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