日常家庭氡暴露与青少年大脑结构形态的改变有关

IF 3.4 3区 医学 Q2 NEUROSCIENCES Neurotoxicology Pub Date : 2024-05-01 DOI:10.1016/j.neuro.2024.04.007
OgheneTejiri V. Smith , Samantha H. Penhale , Lauren R. Ott , Danielle L. Rice , Anna T. Coutant , Ryan Glesinger , Tony W. Wilson , Brittany K. Taylor
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引用次数: 0

摘要

大脑形态的完善贯穿整个童年时期,在此期间接触环境毒素可能会改变典型的趋势。氡是一种非常常见的放射性毒素,在成人癌症中的作用已得到证实。然而,相比之下,人们对氡对发育人群的影响研究不足。本研究调查了家庭氡暴露是否与青少年大脑形态的改变有关。54名参与者(6-14岁,男=10.52岁,48.15%为男性,89%为白人)完成了T1加权核磁共振成像和家庭氡测量。我们观察到家庭氡浓度的多变量效应非常明显,这主要是受对 GMV 的影响所驱动。具体来说,家庭氡浓度越高,GMV 越小(F=6.800,p=.012,ηp2=.13)。与此相反,氡与年龄之间存在着一种趋势性的相互作用,当考虑到氡暴露的长期性时,这种相互作用达到了显著性(F=4.12,p=.049,ηp2=.09)。我们发现,氡暴露量高于平均水平的青少年的 WMV 没有随着年龄的增长而发生变化,而氡暴露量低的青少年的 WMV 与正常的、与年龄相关的 WMV 增长有关。这些结果表明,日常家庭氡暴露可能会改变敏感的大脑结构发育,影响灰质和白质的发育轨迹。
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Everyday home radon exposure is associated with altered structural brain morphology in youths

The refinement of brain morphology extends across childhood, and exposure to environmental toxins during this period may alter typical trends. Radon is a highly common radiologic toxin with a well-established role in cancer among adults. However, effects on developmental populations are understudied in comparison. This study investigated whether home radon exposure is associated with altered brain morphology in youths. Fifty-four participants (6–14 yrs, M=10.52 yrs, 48.15% male, 89% White) completed a T1-weighted MRI and home measures of radon. We observed a significant multivariate effect of home radon concentrations, which was driven by effects on GMV. Specifically, higher home radon was associated with smaller GMV (F=6.800, p=.012, ηp2=.13). Conversely, there was a trending radon-by-age interaction on WMV, which reached significance when accounting for the chronicity of radon exposure (F=4.12, p=.049, ηp2=.09). We found that youths with above-average radon exposure showed no change in WMV with age, whereas low radon was linked with normative, age-related WMV increases. These results suggest that everyday home radon exposure may alter sensitive structural brain development, impacting developmental trajectories in both gray and white matter.

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来源期刊
Neurotoxicology
Neurotoxicology 医学-毒理学
CiteScore
6.80
自引率
5.90%
发文量
161
审稿时长
70 days
期刊介绍: NeuroToxicology specializes in publishing the best peer-reviewed original research papers dealing with the effects of toxic substances on the nervous system of humans and experimental animals of all ages. The Journal emphasizes papers dealing with the neurotoxic effects of environmentally significant chemical hazards, manufactured drugs and naturally occurring compounds.
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