{"title":"利用液相电子显微镜对生物大分子的作用进行成像","authors":"Jia-ye Li, He Sun, Huan Wang","doi":"10.1016/j.trechm.2024.04.004","DOIUrl":null,"url":null,"abstract":"<p>Imaging biomacromolecules in action in a liquid environment poses a challenge to single-molecule experiments. Liquid-phase electron microscopy (LP-EM) has demonstrated its unique ability to reveal previously unseen transient dynamics and intermediate states of delicate biomacromolecular systems (protein, DNA/RNA) with deep-learning methods and careful evaluation of electron beam effects.</p>","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"17 1","pages":""},"PeriodicalIF":14.0000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Imaging biomacromolecules in action with liquid-phase electron microscopy\",\"authors\":\"Jia-ye Li, He Sun, Huan Wang\",\"doi\":\"10.1016/j.trechm.2024.04.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Imaging biomacromolecules in action in a liquid environment poses a challenge to single-molecule experiments. Liquid-phase electron microscopy (LP-EM) has demonstrated its unique ability to reveal previously unseen transient dynamics and intermediate states of delicate biomacromolecular systems (protein, DNA/RNA) with deep-learning methods and careful evaluation of electron beam effects.</p>\",\"PeriodicalId\":48544,\"journal\":{\"name\":\"Trends in Chemistry\",\"volume\":\"17 1\",\"pages\":\"\"},\"PeriodicalIF\":14.0000,\"publicationDate\":\"2024-05-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1016/j.trechm.2024.04.004\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.trechm.2024.04.004","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Imaging biomacromolecules in action with liquid-phase electron microscopy
Imaging biomacromolecules in action in a liquid environment poses a challenge to single-molecule experiments. Liquid-phase electron microscopy (LP-EM) has demonstrated its unique ability to reveal previously unseen transient dynamics and intermediate states of delicate biomacromolecular systems (protein, DNA/RNA) with deep-learning methods and careful evaluation of electron beam effects.
期刊介绍：
Trends in Chemistry serves as a new global platform for discussing significant and transformative concepts across all areas of chemistry. It recognizes that breakthroughs in chemistry hold the key to addressing major global challenges. The journal offers readable, multidisciplinary articles, including reviews, opinions, and short pieces, designed to keep both students and leading scientists updated on pressing issues in the field.
Covering analytical, inorganic, organic, physical, and theoretical chemistry, the journal highlights major themes such as biochemistry, catalysis, environmental chemistry, materials, medicine, polymers, and supramolecular chemistry. It also welcomes articles on chemical education, health and safety, policy and public relations, and ethics and law.
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