减少男性大量饮酒的度他雄胺随机安慰剂对照临床试验。

IF 2.9 3区医学 Q2 PHARMACOLOGY & PHARMACY Journal of Clinical Psychopharmacology Pub Date : 2024-04-29 DOI:10.1097/jcp.0000000000001849

Jonathan Covault, Howard Tennen, Richard Feinn

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引用次数: 0

摘要

先前的研究表明，神经活性类固醇介导了酒精的某些作用。被广泛用于治疗良性前列腺肥大的度他雄胺是5-α还原酶的抑制剂，而5-α还原酶在产生5α还原型神经活性类固醇的过程中起着核心作用。本研究旨在测试度他雄胺对减少饮酒的耐受性和疗效。

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Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men.

Prior studies indicate that neuroactive steroids mediate some of alcohol's effects. Dutasteride, widely used to treat benign prostatic hypertrophy, is an inhibitor of 5-alpha reductase enzymes, which play a central role in the production of 5α-reduced neuroactive steroids. The purpose of this study was to test dutasteride's tolerability and efficacy for reducing drinking.

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来源期刊

Journal of Clinical Psychopharmacology 医学-精神病学

CiteScore

4.00

自引率

3.40%

发文量

231

审稿时长

4-8 weeks

期刊介绍： Journal of Clinical Psychopharmacology, a leading publication in psychopharmacology, offers a wide range of articles reporting on clinical trials and studies, side effects, drug interactions, overdose management, pharmacogenetics, pharmacokinetics, and psychiatric effects of non-psychiatric drugs. The journal keeps clinician-scientists and trainees up-to-date on the latest clinical developments in psychopharmacologic agents, presenting the extensive coverage needed to keep up with every development in this fast-growing field.