利用生成式对抗网络和受限构造优化技术设计异构微血管树的硅设计

IF 1.9 4区 医学 Q3 HEMATOLOGY Microcirculation Pub Date : 2024-05-01 DOI:10.1111/micc.12854
Qing Pan, Huanghui Shen, Peilun Li, Biyun Lai, Akang Jiang, Wenjie Huang, Fei Lu, Hong Peng, Luping Fang, Wolfgang M. Kuebler, Axel R. Pries, Gangmin Ning
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引用次数: 0

摘要

目的设计生理上适当的微血管树对于生物工程功能组织和器官至关重要。然而,目前可用的方法并不适合复制真实微血管树的形态和拓扑异质性,因为用于控制微血管树生成的参数过于简单,无法模拟体内复杂的血管生成和结构适应过程的结果。cDCGAN 可以学习真实微血管分叉的模式,从而进行人工复制。结果生成的人工微血管树在分形维度、血管密度以及直径、长度和迂曲度的变异系数等特征方面与真实微血管树一致。
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In Silico Design of Heterogeneous Microvascular Trees Using Generative Adversarial Networks and Constrained Constructive Optimization

Objective

Designing physiologically adequate microvascular trees is of crucial relevance for bioengineering functional tissues and organs. Yet, currently available methods are poorly suited to replicate the morphological and topological heterogeneity of real microvascular trees because the parameters used to control tree generation are too simplistic to mimic results of the complex angiogenetic and structural adaptation processes in vivo.

Methods

We propose a method to overcome this limitation by integrating a conditional deep convolutional generative adversarial network (cDCGAN) with a local fractal dimension-oriented constrained constructive optimization (LFDO-CCO) strategy. The cDCGAN learns the patterns of real microvascular bifurcations allowing for their artificial replication. The LFDO-CCO strategy connects the generated bifurcations hierarchically to form microvascular trees with a vessel density corresponding to that observed in healthy tissues.

Results

The generated artificial microvascular trees are consistent with real microvascular trees regarding characteristics such as fractal dimension, vascular density, and coefficient of variation of diameter, length, and tortuosity.

Conclusions

These results support the adoption of the proposed strategy for the generation of artificial microvascular trees in tissue engineering as well as for computational modeling and simulations of microcirculatory physiology.

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来源期刊
Microcirculation
Microcirculation 医学-外周血管病
CiteScore
5.00
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
期刊最新文献
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