肌痛性脑脊髓炎/慢性疲劳综合征的表观遗传学重编程:潜伏病毒的叙述

IF 9 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Journal of Internal Medicine Pub Date : 2024-05-01 DOI:10.1111/joim.13792
Eirini Apostolou, Anders Rosén
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引用次数: 0

摘要

肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)是一种慢性疾病,表现为严重疲劳、劳累后乏力和认知障碍等一系列症状,这些症状共同导致患者无法出门或卧床不起。对 ME/CFS 的表观遗传学研究共同证实,与免疫反应、细胞新陈代谢、细胞死亡和增殖、神经元和内皮细胞功能相关的细胞和机体生理学发生了改变和/或故障。ME/CFS是在一个主要的应激因素之后突然发生的,在大约70%的病例中涉及病毒感染,ME/CFS的症状与长期COVID的症状重叠。与 ME/CFS 病理有关的病毒主要是共生疱疹病毒,其生命周期为二价潜伏-裂解周期。病毒和宿主之间复杂的相互作用涉及双方的策略:病毒的免疫逃避和持续存在,以及宿主的免疫激活和病毒清除。疱疹病毒通过对自身和宿主基因组的表观遗传调控来促进其持续存在,这种动态的相互作用对于疱疹病毒来说是必不可少的。在这篇文章中,我们概述了在 ME/CFS 中显示的表观遗传特征,并重点探讨了潜伏病毒(尤其是 Epstein-Barr 病毒)在 ME/CFS 中长期表观遗传重编程过程中可能采用的潜在策略。表观遗传学研究有助于阐明影响 ME/CFS 的相关生物通路,并反映出患者因环境诱因(包括外源性病毒和/或病毒活性改变)而产生的生理差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Epigenetic reprograming in myalgic encephalomyelitis/chronic fatigue syndrome: A narrative of latent viruses

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disease presenting with severe fatigue, post-exertional malaise, and cognitive disturbances—among a spectrum of symptoms—that collectively render the patient housebound or bedbound. Epigenetic studies in ME/CFS collectively confirm alterations and/or malfunctions in cellular and organismal physiology associated with immune responses, cellular metabolism, cell death and proliferation, and neuronal and endothelial cell function. The sudden onset of ME/CFS follows a major stress factor that, in approximately 70% of cases, involves viral infection, and ME/CFS symptoms overlap with those of long COVID. Viruses primarily linked to ME/CFS pathology are the symbiotic herpesviruses, which follow a bivalent latent–lytic lifecycle. The complex interaction between viruses and hosts involves strategies from both sides: immune evasion and persistence by the viruses, and immune activation and viral clearance by the host. This dynamic interaction is imperative for herpesviruses that facilitate their persistence through epigenetic regulation of their own and the host genome. In the current article, we provide an overview of the epigenetic signatures demonstrated in ME/CFS and focus on the potential strategies that latent viruses—particularly Epstein–Barr virus—may employ in long-term epigenetic reprograming in ME/CFS. Epigenetic studies could aid in elucidating relevant biological pathways impacted in ME/CFS and reflect the physiological variations among the patients that stem from environmental triggers, including exogenous viruses and/or altered viral activity.

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来源期刊
Journal of Internal Medicine
Journal of Internal Medicine 医学-医学:内科
CiteScore
22.00
自引率
0.90%
发文量
176
审稿时长
4-8 weeks
期刊介绍: JIM – The Journal of Internal Medicine, in continuous publication since 1863, is an international, peer-reviewed scientific journal. It publishes original work in clinical science, spanning from bench to bedside, encompassing a wide range of internal medicine and its subspecialties. JIM showcases original articles, reviews, brief reports, and research letters in the field of internal medicine.
期刊最新文献
Therapeutic BCG vaccine protects against long COVID: The BATTLE randomized clinical trial. Different ways of diagnosing selective glomerular hypofiltration syndromes such as shrunken pore syndrome and the associated increase in mortality. Statin-associated regulation of hepatic PNPLA3 in patients without known liver disease. Issue Information Association among major adverse cardiovascular events with immune checkpoint inhibitors: A systematic review and meta-analysis.
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