secukinumab在沙特真实世界环境中对银屑病和银屑病关节炎患者的疗效

IF 2 4区 医学 Q3 RHEUMATOLOGY Advances in Rheumatology Pub Date : 2024-04-29 DOI:10.1186/s42358-024-00371-1
Ibrahim A. Al-Homood, Mohammed Alajlan, Majid Alberdisi, Mohammad Alturki, Ahmed Ali Ahmed, Nancy Zakaria
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引用次数: 0

摘要

银屑病(PsO)是一种免疫介导的慢性炎症性疾病,严重影响患者的生活质量和工作效率。我们调查了 secukinumab 在 12 个月内对慢性斑块状银屑病和银屑病关节炎(PsA)患者的疗效。这是一项纵向回顾性研究,研究对象是81名接受secukinumab治疗至少12周的银屑病和/或银屑病关节炎患者的病历。银屑病和银屑病关节炎患者的银屑病面积严重指数(PASI)、体表面积(BSA)百分比和皮肤病生活质量指数(DLQI)在12个月内分别比基线值下降了约9.86%、19.3%和9.7%,差异有统计学意义(P值均小于0.001)。此外,在12个月的治疗期间,银屑病关节炎疾病活动性总评分(DAPSA)比基线值下降了约22.35(P值<0.001),具有统计学意义。考虑到在研究截止日期前 12 个月或更早开始使用 secukinumab 的患者,12 个月的保留率为 85%。在沙特的真实世界环境中,secukinumab被证明是一种高效药物,具有很高的疗效和保留率。
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Effectiveness of secukinumab in patients with psoriasis and psoriatic arthritis in a Saudi real-world setting
Psoriasis (PsO) is an immune-mediated chronic inflammatory disease that results in severe outcomes that impact the patient’s quality of life and work productivity. We investigated the effectiveness of secukinumab in patients with chronic plaque psoriasis and psoriatic arthritis (PsA) over a 12-month period. This was a longitudinal, retrospective study of the medical records of 81 patients with psoriasis and/or psoriatic arthritis who had been treated with secukinumab for at least 12 weeks. The Psoriasis Area Severity Index (PASI), Body Surface Area (BSA) percentage, and Dermatology Quality of Life Index (DLQI) among patients with PsO and PsO-PsA showed a statistically significant decrease from baseline over 12 months by approximately 9.86, 19.3%, and 9.7, respectively (p values < 0.001 for each). Moreover, there was a statistically significant decrease in the overall Disease Activity in Psoriatic Arthritis score (DAPSA) by approximately 22.35 from baseline over 12 months of treatment (p < 0.001). Considering the patients who started secukinumab 12 months or more prior to the study cutoff date, the 12-month retention rate was 85%. In a Saudi real-world setting, secukinumab proved to be an efficient medication with high efficacy and retention rates.
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来源期刊
Advances in Rheumatology
Advances in Rheumatology Medicine-Rheumatology
CiteScore
4.00
自引率
4.30%
发文量
41
审稿时长
53 weeks
期刊介绍: Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.
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