姜黄素通过减少细胞凋亡和氧化应激来延缓大脑衰老

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-04-30 DOI:10.1007/s11011-023-01326-z
Mehran Cheriki, Masoumeh Habibian, Seyyed Jafar Moosavi
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引用次数: 0

摘要

大脑衰老是一种生理现象,氧化应激和细胞凋亡参与了大脑的自然衰老过程。姜黄素是一种天然抗氧化剂,具有很强的抗衰老和神经保护作用。因此,我们研究了姜黄素对老年大鼠脑凋亡和氧化应激、脑源性神经营养因子(BDNF)和血管内皮生长因子(VEGF)的保护作用。将老龄雌性 Wistar 大鼠随机分为以下三组(n = 7):(1)对照组;(2)生理盐水组;(3)姜黄素组(腹腔注射姜黄素 30 毫克/千克,每周 5 天,连续 8 周)。我们的研究结果表明,姜黄素能减轻老年大鼠的脑脂质过氧化反应,同时BDNF、血管内皮生长因子、超氧化物歧化酶(SOD)活性和抗凋亡蛋白BCl-2也显著增加。姜黄素治疗后,脑部抗凋亡蛋白Bax水平未见明显变化。研究表明,姜黄素能缓解大脑衰老,这可能是由于姜黄素能减轻氧化应激、抑制细胞凋亡、上调 SOD 活性,进而增强血管内皮生长因子和 BDNF。因此,姜黄素在治疗脑衰老引起的神经系统凋亡、神经发生和血管生成变化方面具有潜在的治疗价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Curcumin attenuates brain aging by reducing apoptosis and oxidative stress

Brain aging is a physiological event, and oxidative stress and apoptosis are involved in the natural aging process of the brain. Curcumin is a natural antioxidant with potent anti-aging and neuroprotective properties. Therefore, we investigated the protective effects of curcumin on brain apoptosis and oxidative stress, brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) in aged rats. Old female Wistar rats were randomly divided into three groups (n = 7); as follows: (1) control; (2); saline and (3) curcumin (received 30 mg/kg of curcumin, 5 days/week for 8 weeks, intraperitoneally). Our results indicated that treatment with curcumin in aged rats attenuates brain lipid peroxidation, which was accompanied by a significant increase in the BDNF, VEGF, superoxide dismutase (SOD) activity, and anti-apoptotic protein BCl-2. No significant change in brain anti-apoptotic Bax protein levels was observed after curcumin treatment. The study indicates that curcumin could alleviate brain aging which may be due to attenuating oxidative stress, inhibiting apoptosis, and up-regulating SOD activity, which in turn enhances VEGF and BDNF. Therefore, curcumin has potential therapeutic value in the treatment of neurological apoptosis, neurogenesis, and angiogenesis changes caused by brain aging.

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CiteScore
7.20
自引率
4.30%
发文量
567
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