糖尿病雌性大鼠海马中 tau(而非 beta-淀粉样蛋白)水平的变化可能是运动改善焦虑样行为的介导因素

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES Behavioral and Brain Functions Pub Date : 2024-05-03 DOI:10.1186/s12993-024-00235-0
Kayvan Khoramipour, Maryam Hossein Rezaei, Amirhossein Moslemizadeh, Mahdieh Sadat Hosseini, Narjes Ebrahimnezhad, Hamideh Bashiri
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引用次数: 0

摘要

本研究探讨了高强度间歇训练(HIIT)对高脂饮食+链脲佐菌素(STZ)诱导的2型糖尿病雌性大鼠认知行为的影响。24 只雌性大鼠被随机分为四组(n = 6):对照组(C)、对照组 + 运动组(Co + EX)、糖尿病(2 型)组(T2D)和糖尿病 + 运动组(T2D + EX)。T2D组和T2D + EX组通过为期两个月的高脂饮食和单剂量STZ(35毫克/千克)诱发糖尿病。Co + EX组和T2D + EX组进行为期八周的HIIT训练(每周五次,在跑步机上以80-100%的VMax速度跑步,每次间隔4-10分钟)。高架加迷宫(EPM)和开阔地测试(OFT)用于评估焦虑样行为,被动回避测试(PAT)和莫里斯水迷宫(MWM)用于评估学习和记忆。此外,还利用Western印迹技术评估了海马中β-淀粉样蛋白(Aβ)和Tau的水平。结果显示,雌性糖尿病大鼠空腹血糖(FBG)升高,海马Tau水平升高,作为焦虑样行为指标的开臂时间百分比(%OAT)下降,而HIIT可以逆转这些变化。此外,T2D 还导致雌性糖尿病大鼠在 OFT 中的饲养和梳理行为显著减少。在 PAT 的潜伏时间以及 MWM 的学习和记忆方面,各组之间没有明显差异。HIIT至少在一定程度上可以通过改变海马的Tau水平来改善焦虑样行为。
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Changes in the hippocampal level of tau but not beta-amyloid may mediate anxiety-like behavior improvement ensuing from exercise in diabetic female rats
In the present study, we investigated the effect of high-intensity interval training (HIIT) on cognitive behaviors in female rats with a high-fat diet + streptozotocin (STZ)-induced type 2 diabetes. Twenty-four female rats were divided into four groups randomly (n = 6): control (C), control + exercise (Co + EX), diabetes mellitus (type 2) (T2D), and diabetes mellitus + exercise (T2D + EX). Diabetes was induced by a two-month high-fat diet and a single dose of STZ (35 mg/kg) in the T2D and T2D + EX groups. The Co + EX and T2D + EX groups performed HIIT for eight weeks (five sessions per week, running on a treadmill at 80–100% of VMax, 4–10 intervals). Elevated plus maze (EPM) and open field test (OFT) were used for assessing anxiety-like behaviors, and passive avoidance test (PAT) and Morris water maze (MWM) were applied for evaluating learning and memory. The hippocampal levels of beta-amyloid (Aβ) and Tau were also assessed using Western blot. An increase in fasting blood glucose (FBG), hippocampal level of Tau, and a decrease in the percentage of open arm time (%OAT) as an index of anxiety-like behavior were seen in the female diabetic rats which could be reversed by HIIT. In addition, T2D led to a significant decrease in rearing and grooming in the OFT. No significant difference among groups was seen for the latency time in the PAT and learning and memory in the MWM. HIIT could improve anxiety-like behavior at least in part through changes in hippocampal levels of Tau.
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来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
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