[肺部炎症性疾病中 PD-L1 的研究进展]。

Q3 Medicine 生理学报 Pub Date : 2024-04-25

A-Guo Li, Ai-Hua Cai, Hao-Ji Li, Qi-Ying Huang, Yong-Sheng Tu

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引用次数: 0

摘要

程序性死亡配体 1（PD-L1）在维持正常组织的中枢和外周免疫耐受、介导肿瘤免疫逃逸以及保持抗炎和促炎反应之间的平衡方面具有重要作用。炎症在肺部炎症性疾病中发挥着重要作用。本文综述了 PD-L1 在肺部炎症性疾病（包括急性肺损伤、慢性阻塞性肺疾病、哮喘和特发性肺纤维化）中的研究进展和潜在临床价值。

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[Research progress of PD-L1 in inflammatory lung diseases].

Programmed death-ligand 1 (PD-L1) is important in maintaining central and peripheral immune tolerance in normal tissues, mediating tumor immune escape and keeping the balance between anti- and pro-inflammatory responses. Inflammation plays an important role in inflammatory lung diseases. This article reviews the research progress and potential clinical value of PD-L1 in inflammatory lung diseases, including acute lung injury, chronic obstructive pulmonary disease, asthma and idiopathic pulmonary fibrosis.

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.