{"title":"KCNJ5突变醛固酮分泌腺瘤的心血管预后:系统综述。","authors":"Hajime Kato MD, PhD , Takumi Kitamoto MD, PhD , Soichiro Kimura MD , Takashi Sunouchi MD , Yoshitomo Hoshino MD , Naoko Hidaka MD , Yuya Tsurutani MD, PhD , Nobuaki Ito MD, PhD , Noriko Makita MD, PhD , Tetsuo Nishikawa MD, PhD , Masaomi Nangaku MD, PhD , Kosuke Inoue MD, PhD","doi":"10.1016/j.eprac.2024.04.007","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>While clinical features of <em>KCNJ5</em>-mutated aldosterone-producing adenoma (APA) have been reported, evidence of its clinical outcomes is lacking. We aimed to synthesize available literature about the associations between <em>KCNJ5</em> mutation with cardiovascular and metabolic outcomes among patients with APA.</p></div><div><h3>Methods</h3><p>In this systematic review of observational studies, MEDLINE and Embase were searched through August 2022. Two independent authors screened the search results and extracted data from eligible observational studies investigating cardiovascular or metabolic outcomes between <em>KCNJ5</em>-mutated APAs and <em>KCNJ5</em>-non-mutated APAs. Risk of Bias In Non-randomized Studies of Interventions was used to assess the quality of the included studies.</p></div><div><h3>Results</h3><p>A total of 573 titles/abstracts were screened and after the expert opinion of the literature, full text was read in 20 titles/abstracts, of which 12 studies were included. Across 3 studies comparing the baseline or change in the cardiac function between <em>KCNJ5</em>-mutated APAs and <em>KCNJ5</em>-non-mutated APAs, all studies reported the association between impaired cardiac functions and <em>KCNJ5</em> mutation status. Among 6 studies evaluating the cure of hypertension after surgery, all studies showed that <em>KCNJ5</em> mutation was significantly associated with the cure of hypertension. In quality assessment, 7 studies were at serious risk of bias, while the remaining studies were at moderate risk of bias.</p></div><div><h3>Conclusions</h3><p>This systematic review provided evidence of the significant association between <em>KCNJ5</em> mutation and unfavorable cardiovascular outcomes in patients with primary aldosteronism. Further research is needed to improve the quality of evidence on this topic and elucidate the underlying mechanisms of the potential burden of <em>KCNJ5</em> mutation.</p></div>","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cardiovascular Outcomes of KCNJ5 Mutated Aldosterone-Producing Adenoma: A Systematic Review\",\"authors\":\"Hajime Kato MD, PhD , Takumi Kitamoto MD, PhD , Soichiro Kimura MD , Takashi Sunouchi MD , Yoshitomo Hoshino MD , Naoko Hidaka MD , Yuya Tsurutani MD, PhD , Nobuaki Ito MD, PhD , Noriko Makita MD, PhD , Tetsuo Nishikawa MD, PhD , Masaomi Nangaku MD, PhD , Kosuke Inoue MD, PhD\",\"doi\":\"10.1016/j.eprac.2024.04.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>While clinical features of <em>KCNJ5</em>-mutated aldosterone-producing adenoma (APA) have been reported, evidence of its clinical outcomes is lacking. We aimed to synthesize available literature about the associations between <em>KCNJ5</em> mutation with cardiovascular and metabolic outcomes among patients with APA.</p></div><div><h3>Methods</h3><p>In this systematic review of observational studies, MEDLINE and Embase were searched through August 2022. Two independent authors screened the search results and extracted data from eligible observational studies investigating cardiovascular or metabolic outcomes between <em>KCNJ5</em>-mutated APAs and <em>KCNJ5</em>-non-mutated APAs. Risk of Bias In Non-randomized Studies of Interventions was used to assess the quality of the included studies.</p></div><div><h3>Results</h3><p>A total of 573 titles/abstracts were screened and after the expert opinion of the literature, full text was read in 20 titles/abstracts, of which 12 studies were included. Across 3 studies comparing the baseline or change in the cardiac function between <em>KCNJ5</em>-mutated APAs and <em>KCNJ5</em>-non-mutated APAs, all studies reported the association between impaired cardiac functions and <em>KCNJ5</em> mutation status. Among 6 studies evaluating the cure of hypertension after surgery, all studies showed that <em>KCNJ5</em> mutation was significantly associated with the cure of hypertension. In quality assessment, 7 studies were at serious risk of bias, while the remaining studies were at moderate risk of bias.</p></div><div><h3>Conclusions</h3><p>This systematic review provided evidence of the significant association between <em>KCNJ5</em> mutation and unfavorable cardiovascular outcomes in patients with primary aldosteronism. Further research is needed to improve the quality of evidence on this topic and elucidate the underlying mechanisms of the potential burden of <em>KCNJ5</em> mutation.</p></div>\",\"PeriodicalId\":11682,\"journal\":{\"name\":\"Endocrine Practice\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1530891X2400497X\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine Practice","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1530891X2400497X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Cardiovascular Outcomes of KCNJ5 Mutated Aldosterone-Producing Adenoma: A Systematic Review
Background
While clinical features of KCNJ5-mutated aldosterone-producing adenoma (APA) have been reported, evidence of its clinical outcomes is lacking. We aimed to synthesize available literature about the associations between KCNJ5 mutation with cardiovascular and metabolic outcomes among patients with APA.
Methods
In this systematic review of observational studies, MEDLINE and Embase were searched through August 2022. Two independent authors screened the search results and extracted data from eligible observational studies investigating cardiovascular or metabolic outcomes between KCNJ5-mutated APAs and KCNJ5-non-mutated APAs. Risk of Bias In Non-randomized Studies of Interventions was used to assess the quality of the included studies.
Results
A total of 573 titles/abstracts were screened and after the expert opinion of the literature, full text was read in 20 titles/abstracts, of which 12 studies were included. Across 3 studies comparing the baseline or change in the cardiac function between KCNJ5-mutated APAs and KCNJ5-non-mutated APAs, all studies reported the association between impaired cardiac functions and KCNJ5 mutation status. Among 6 studies evaluating the cure of hypertension after surgery, all studies showed that KCNJ5 mutation was significantly associated with the cure of hypertension. In quality assessment, 7 studies were at serious risk of bias, while the remaining studies were at moderate risk of bias.
Conclusions
This systematic review provided evidence of the significant association between KCNJ5 mutation and unfavorable cardiovascular outcomes in patients with primary aldosteronism. Further research is needed to improve the quality of evidence on this topic and elucidate the underlying mechanisms of the potential burden of KCNJ5 mutation.
期刊介绍:
Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.