痴呆症的基因组学见解:精准医学与基因环境相互作用的影响。

IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY Aging and Disease Pub Date : 2024-10-01 DOI:10.14336/AD.2024.0322
Anjali Tripathi, Vinay Kumar Pandey, Garima Sharma, Ashish Ranjan Sharma, Anam Taufeeq, Abhimanyu Kumar Jha, Jin-Chul Kim
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引用次数: 0

摘要

痴呆症是一种慢性认知障碍疾病,其诊断、治疗和管理面临着巨大挑战。基因与环境相互作用的影响进一步凸显了这种疾病的复杂性。最近的一项战略结合了先进的基因组学和精准医学方法,以探索痴呆症复杂的遗传基础。利用神经遗传学领域的最新研究成果,可以研究精确遗传数据在解释痴呆症患者变异方面的重要性。基因与环境之间的相互作用非常重要,因为它们会影响遗传易感性,并有助于痴呆症的发生和发展。根据每位患者的遗传特征进行修改后,精准医疗就有可能发现高危人群,并对疾病的进程做出前所未闻的预测。精准医疗技术有可能彻底改变治疗和诊断方法。针对基因异常的靶向药物很可能会出现,从而为更高效、更个性化的医疗干预提供可能。研究基因与环境之间的关系可能会产生预防措施,使人们能够改变周围环境,最大限度地降低患痴呆症的风险,从而改善患者的生活方式。本文全面概述了痴呆症的基因组学研究,强调了精准医疗以及基因与环境相互作用的关键作用。
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Genomic Insights into Dementia: Precision Medicine and the Impact of Gene-Environment Interaction.

The diagnosis, treatment, and management of dementia provide significant challenges due to its chronic cognitive impairment. The complexity of this condition is further highlighted by the impact of gene-environment interactions. A recent strategy combines advanced genomics and precision medicine methods to explore the complex genetic foundations of dementia. Utilizing the most recent research in the field of neurogenetics, the importance of precise genetic data in explaining the variation seen in dementia patients can be investigated. Gene-environment interactions are important because they influence genetic susceptibilities and aid in the development and progression of dementia. Modified to each patient's genetic profile, precision medicine has the potential to detect groups at risk and make previously unheard-of predictions about the course of diseases. Precision medicine techniques have the potential to completely transform treatment and diagnosis methods. Targeted medications that target genetic abnormalities will probably appear, providing the possibility for more efficient and customized medical interventions. Investigating the relationship between genes and the environment may lead to preventive measures that would enable people to change their surroundings and minimize the risk of dementia, leading to the improved lifestyle of affected people. This paper provides a comprehensive overview of the genomic insights into dementia, emphasizing the pivotal role of precision medicine, and gene-environment interactions.

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来源期刊
Aging and Disease
Aging and Disease GERIATRICS & GERONTOLOGY-
CiteScore
14.60
自引率
2.70%
发文量
138
审稿时长
10 weeks
期刊介绍: Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.
期刊最新文献
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