肝移植可逆转肝硬化失代偿期的肝脊髓病:病例报告与文献综述。

IF 3.1 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Journal of Clinical and Translational Hepatology Pub Date : 2024-04-28 Epub Date: 2024-03-13 DOI:10.14218/JCTH.2023.00487
Jiajun Li, Sile Wan, Fukai Wen, Qingyu Li, Yifeng Cui, Zhaoyang Lu, Han Lin
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引用次数: 0

摘要

肝性脊髓病(HM)是许多肝病晚期一种罕见的神经系统并发症,其特征是双侧痉挛性瘫痪,但无感觉和括约肌功能障碍。它的发生是由于肝硬化引起的代谢紊乱和中枢神经系统功能障碍。如果没有及时有效的临床干预,这些患者的预后将是毁灭性的。虽然肝移植(LT)是治疗 HM 的有效方法,但这些患者的预后仍不令人满意。早期识别和诊断这种疾病对于改善患者的预后至关重要。在此,我们报告了一例乙型肝炎病毒相关性失代偿期肝硬化合并 HM 的病例。患者在接受长期治疗后恢复良好。我们还总结了截至 2023 年,包括本病例在内的 25 例接受 LT 治疗的 HM 患者的临床特征和移植后预后。
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Liver Transplantation Reverses Hepatic Myelopathy in the Decompensated Phase of Cirrhosis: Case Report and Literature Review.

Hepatic myelopathy (HM) is a rare neurological complication in the end stage of many liver diseases and is characterized by bilateral spastic paraparesis without sensory and sphincter dysfunction. It occurs owing to metabolic disorders and central nervous system dysfunction associated with cirrhosis. Without timely and effective clinical intervention, the prognosis of these patients is devastating. Although liver transplantation (LT) is an effective treatment for HM, the prognosis of these patients remains unsatisfactory. Early recognition and diagnosis of this disease are essential for improving patient prognosis. Here, we report a case of hepatitis B virus-associated decompensated cirrhosis with HM. The patient recovered well after LT. We also summarize the clinical characteristics and post-transplant outcomes of 25 patients with HM treated by LT through 2023, including this case.

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来源期刊
Journal of Clinical and Translational Hepatology
Journal of Clinical and Translational Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
6.40
自引率
2.80%
发文量
496
期刊最新文献
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