自噬在接受抗病毒治疗的慢性乙型肝炎患者肝纤维化进展中的潜在作用:简要报告。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2024-03-01 DOI:10.30476/ijms.2023.96588.2813
Kamran Bagheri Lankarani, Atefeh Sadidoost, Mohammadreza Fattahi, Saeid Amirizadeh Fard, Pooneh Mokarram
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引用次数: 0

摘要

尽管接受了抗病毒治疗,一些慢性乙型肝炎(CHB)患者仍会发展为肝硬化。自噬的增强与乙型肝炎在肝细胞中的增殖有关。本研究旨在评估自噬在接受抗病毒治疗并完全抑制病毒复制的患者肝纤维化进展过程中的潜在作用。这项描述性分析研究于 2020 年在伊朗设拉子医科大学附属 Mottahhari 肝炎诊所(伊朗设拉子)设计和实施。病例组包括接受抗乙型肝炎核苷酸治疗至少两年的患者,以及基线时未患肝硬化但后来发展为肝硬化的患者。此外,在对照组中,随机选取了接受核苷酸治疗但在基线或随访期间未出现肝硬化的患者。研究最终纳入了 16 例病例和 14 例对照。研究使用 SPSS 软件对数据进行分析,并使用 Pt 检验来评估病例组和对照组之间的统计学差异。肝硬化患者的Beclin-1水平明显高于对照组(1283±244 vs. 1063±257,P=0.024)。然而,肝硬化组(168±31)和对照组(150±16)的 LC3 水平无统计学差异(P=0.065)。自噬可能在慢性乙型肝炎患者肝硬化的进展过程中发挥作用。未来需要进行更大规模的前瞻性研究,以确定阻断对该人群肝病进展的影响。本研究的预印本发表于 https://www.researchsquare.com/article/rs-1435490/v1.pdf。
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The Potential Role of Autophagy in Progression of Liver Fibrosis in Chronic Hepatitis B Patients Receiving Antiviral Treatment: A Brief Report.

Despite antiviral treatment, some patients with chronic hepatitis B (CHB) progress to cirrhosis. Enhancement of autophagy was implicated in the proliferation of hepatitis B in hepatocytes. This study aimed to evaluate the potential role of autophagy in the progression of liver fibrosis in patients receiving antiviral treatments and having completely inhibited viral replication. This descriptive-analytical study was designed and conducted in 2020 at Mottahhari Hepatitis Clinic affiliated with Shiraz University of Medical Science (Shiraz, Iran). Patients who were on anti-hepatitis B nucleotide treatments for at least two years, and those who were not cirrhotic at baseline but later progressed to cirrhosis were identified to be included in the case group. Besides, for the control group, patients on the nucleotide regimens who did not have cirrhosis at baseline or during follow-up were randomly selected. Ultimately, 16 cases and 14 controls were included in the study. Data were analyzed using SPSS software, and P<0.05 was considered statistically significant. Serum Beclin-1 and LC3 levels were compared between the two groups using enzyme-linked immunosorbent assays. The t test was used to assess the statistical differences between the case and control groups. Beclin-1 level was significantly higher in cirrhosis patients than the control group (1283±244 vs. 1063±257, P=0.024). However, there was no statistical difference between the level of LC3 in the cirrhotic group (168±31) and the control group (150±16) (P=0.065). Autophagy may have a role in the progression of cirrhosis in patients with CHB. Future larger prospective studies are required to determine the effect of blocking on the progression of liver disease in this population A preprint of this study was published at https://www.researchsquare.com/article/rs-1435490/v1.pdf.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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