迷迭香酸可保护大鼠睾丸免受手机和超高频波诱导的毒性影响

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2024-04-01 DOI:10.30476/ijms.2023.97695.2952
Jafar Fatahi Asl, Mehdi Goudarzi, Esrafil Mansouri, Hamed Shoghi
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引用次数: 0

摘要

背景:手机和超高频(UHF)会产生氧化应激并导致睾丸中毒。本研究旨在评估迷迭香酸(RA)对超高频辐射导致的大鼠氧化应激的有效性:方法:42 只雄性 Wistar 大鼠分为 6 组。对照组灌胃 5 mL 生理盐水(0.9% NaCl),手机组接受 915 MHz 频率辐射,超高频电波组仅接受 2450 MHz 频率辐射,RA/手机组接受 RA 加 915 MHz 频率辐射,RA/超高频电波组接受 RA 加 2450 MHz 频率辐射,RA 组仅接受 RA(20 mg/kg)。连续辐射 30 天后,测量睾丸的生化和组织病理学参数。统计比较采用单因素方差分析,然后进行Tukey事后检验:结果:手机和超高频辐射明显降低了超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶等抗氧化酶的活性和谷胱甘肽含量(PC):RA可通过减少氧化应激保护大鼠睾丸免受超高频诱导的毒性。作为一种食品补充剂,RA 可能有助于保护暴露于超高频环境污染中的人类。
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Rosmarinic Acid Protects the Testes of Rats against Cell Phone and Ultra-high Frequency Waves Induced Toxicity.

Background: Cell phone and Ultra-High Frequency (UHF) waves produce oxidative stress and cause testicular toxicity. This investigation was directed to evaluate the effectiveness of Rosmarinic Acid (RA) against oxidative stress caused by UHF radiation in rats.

Methods: Forty-two male Wistar rats were divided into six groups. The control received 5 mL normal saline (0.9% NaCl) by gavage, the cell phone group received 915 MHz, the UHF waves group just received 2450 MHz, the RA/cell phone group received RA plus 915 MHz, RA/UHF waves group received RA plus 2450 MHz, and RA just received RA (20 mg/kg). After 30 days of consecutive radiation, the biochemical and histopathological parameters of their testes were measured. Statistical comparison was made using one-way ANOVA followed by Tukey's post hoc test.

Results: Cell phone and UHF wave radiation significantly diminished the activity of antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase, and glutathione content (P<0.001). On the opposite, UHF significantly increased oxidative stress indices including malondialdehyde level, nitric oxide level, and protein carbonyl content (P<0.001). UHF also significantly reduced the number of Sertoli cells, spermatogonia, primary spermatocyte, epithelial height, and seminiferous tubular and luminal diameters (P<0.001). RA, as an effective antioxidant, reverses the above-mentioned harms and moderates the adverse effects of UHF on the testes of rats by significantly diminishing the oxidative stress indices and antioxidant enzyme rise and improving the histological parameters (P<0.001).

Conclusion: RA can protect the testes of rats from UHF-induced toxicity by reducing oxidative stress. RA as a food supplement might be useful for protecting humans exposed to UHF environmental contamination.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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