一例由依托咪酯引起的致命中毒:病理学和毒理学分析的证据。

IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Forensic Science, Medicine and Pathology Pub Date : 2024-12-01 Epub Date: 2024-04-23 DOI:10.1007/s12024-024-00813-8
Yinyu Chen, Jiaqi Liu, Tao Song, Xing Zou, Leilei Li, Qianyun Nie, Peng Zhang
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引用次数: 0

摘要

依托咪酯是一种从咪唑中提取的非巴比妥类镇静剂。长期过量使用依托咪酯可导致肾上腺皮质功能抑制、肌阵挛甚至死亡。本报告描述了一例罕见病例,一名 47 岁的男子在口服含有依托咪酯的液体后死于急性中毒。根据包括尸检、组织病理学检查、毒理学分析和生化分析在内的全面调查,死因最终被确定为依托咪酯。这是报告的首例仅因口服依托咪酯导致死亡的病例,可为今后涉及依托咪酯中毒的法医调查提供宝贵的启示。因此,有必要与科学界分享这一案例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A case of fatal poisoning caused by etomidate: evidence from pathological and toxicological analyses.

Etomidate is a nonbarbiturate sedative derived from imidazole. Prolonged and excessive use of etomidate can lead to the suppression of adrenocortical function, myoclonus, and even death. This report describes a rare case of a 47-year-old man who died from acute intoxication after oral ingestion of liquid containing etomidate. The cause of death was conclusively attributed to etomidate based on a comprehensive investigation, including autopsy, histopathological examination, toxicological analysis, and biochemical analysis. This is the first reported case of a fatality solely resulting from the oral ingestion of etomidate, which can provide valuable insights for future forensic investigations involving etomidate poisoning. Therefore, it is imperative to share this case with the scientific community.

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来源期刊
Forensic Science, Medicine and Pathology
Forensic Science, Medicine and Pathology MEDICINE, LEGAL-PATHOLOGY
CiteScore
3.90
自引率
5.60%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Forensic Science, Medicine and Pathology encompasses all aspects of modern day forensics, equally applying to children or adults, either living or the deceased. This includes forensic science, medicine, nursing, and pathology, as well as toxicology, human identification, mass disasters/mass war graves, profiling, imaging, policing, wound assessment, sexual assault, anthropology, archeology, forensic search, entomology, botany, biology, veterinary pathology, and DNA. Forensic Science, Medicine, and Pathology presents a balance of forensic research and reviews from around the world to reflect modern advances through peer-reviewed papers, short communications, meeting proceedings and case reports.
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