约旦成年人缺乏维生素 D、B6 和 B12 与高脂血症的关系。

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Reports of Biochemistry and Molecular Biology Pub Date : 2023-10-01 DOI:10.61186/rbmb.12.3.415
Madleen Nabil Al-Qusous, Wajdi Khalaf Jamil Al Madanat, Rasha Mohamed Hussein
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引用次数: 0

摘要

背景:肥胖是一种异常的脂肪堆积,会对人体健康产生不利影响。研究报告称,肥胖患者缺乏多种维生素。本研究调查了约旦成人高脂血症患者缺乏维生素 D、B6 和 B12 的情况,并证明了血清维生素水平与代谢和血脂谱参数之间的关联:将 60 名男性受试者分为 40 名高脂血症患者(年龄:45.9 岁 ±10.2)和 20 名对照组(年龄:41.2 岁 ±10.7)。测量血液中甘油三酯、总胆固醇、高密度脂蛋白胆固醇、血红蛋白 A1c 以及维生素 D、B6 和 B12 的含量:结果:与对照组相比,高脂血症患者的甘油三酯、总胆固醇、非高密度脂蛋白、胆固醇/高密度脂蛋白比率、低密度脂蛋白胆固醇水平明显升高,而高密度脂蛋白胆固醇水平下降。各组之间血液中维生素 D、维生素 B6 或维生素 B12 的含量没有明显差异。不过,50% 的高脂血症患者和 54.5% 的对照组患者表现出维生素 D 缺乏。只有高脂血症患者缺乏维生素 B6 和维生素 B12,分别占 5.4% 和 3.3%。在对照组中,维生素 B12 水平与总胆固醇成反比,而在高脂血症患者中,维生素 B6 水平与总胆固醇和非高密度脂蛋白水平成反比:结论:高脂血症患者缺乏维生素 D、B6 和 B12。此外,维生素 B6 和 B12 水平与总胆固醇和非高密度脂蛋白水平成反比。我们的研究结果凸显了对高脂血症患者的维生素水平进行常规评估的重要性。
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Association of Vitamins D, B6, and B12 Deficiencies with Hyperlipidemia Among Jordanian Adults.

Background: Obesity is an abnormal fat accumulation that adversely affects human health. Studies reported several vitamin deficiencies in obese patients. The current study investigates the deficiencies of vitamins D, B6, and B12 among Jordanian adults with hyperlipidemia and demonstrates the association between serum vitamin levels and metabolic and lipid profile parameters.

Methods: Sixty male subjects were divided into 40 hyperlipidemic patients (age: 45.9 yr. ±10.2) and 20 controls (age: 41.2 yr. ±10.7). The blood levels of triglycerides, total cholesterol, high density lipoprotein (HDL)-cholesterol, hemoglobin A1c, and vitamins D, B6, and B12 were measured.

Results: The hyperlipidemic patients showed significantly increased triglycerides, total cholesterol, non-HDL, cholesterol/HDL ratio, low-density lipoprotein (LDL)- cholesterol levels, and decreased HDL-cholesterol levels compared to the controls. No significant differences were found in the blood levels of vitamin D, vitamin B6, or vitamin B12 between groups. However, 50% of the hyperlipidemic patients and 54.5% of the controls exhibited vitamin D deficiency. Only the hyperlipidemic patients exhibited deficiencies of vitamins B6 and B12 in 5.4% and 3.3% of cases, respectively. In the controls, vitamin B12 level was inversely associated with total cholesterol, whereas in the hyperlipidemic patients, vitamin B6 level was inversely correlated with total cholesterol and non-HDL levels.

Conclusions: The hyperlipidemic patients exhibited vitamins D, B6, and B12 deficiencies. Additionally, vitamins B6 and B12 levels were inversely correlated with total cholesterol and non-HDL levels. Our findings highlight the importance of routine evaluation of vitamin levels in patients with hyperlipidemia.

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来源期刊
Reports of Biochemistry and Molecular Biology
Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
2.80
自引率
23.50%
发文量
60
审稿时长
10 weeks
期刊介绍: The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.
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