将抗炎巨噬细胞重编程为促炎巨噬细胞以支持癌症免疫疗法的策略。

IF 3.3 4区医学 Q3 IMMUNOLOGY Immunology letters Pub Date : 2024-05-03 DOI:10.1016/j.imlet.2024.106864

Ana Vizcaino Castro, Toos Daemen, Cesar Oyarce

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引用次数: 0

摘要

包括巨噬细胞和髓源性抑制细胞在内的肿瘤相关髓系细胞在实体瘤中非常普遍，并在肿瘤的发展过程中扮演着重要角色。因此，髓系细胞被认为是癌症免疫疗法的潜在靶点。在这篇综述中，我们重点讨论了针对肿瘤相关巨噬细胞（TAMs）的策略。大多数策略都是临床前研究，但我们也纳入了基于这些策略的少量临床研究。我们描述了可能的内在机制，并讨论了未来的挑战和前景。

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Strategies to reprogram anti-inflammatory macrophages towards pro-inflammatory macrophages to support cancer immunotherapies

Tumor-associated myeloid cells, including macrophages and myeloid-derived suppressor cells, can be highly prevalent in solid tumors and play a significant role in the development of the tumor. Therefore, myeloid cells are being considered potential targets for cancer immunotherapies. In this review, we focused on strategies aimed at targeting tumor-associated macrophages (TAMs). Most strategies were studied preclinically but we also included a limited number of clinical studies based on these strategies. We describe possible underlying mechanisms and discuss future challenges and prospects.

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来源期刊

Immunology letters 医学-免疫学

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

44 days

期刊介绍： Immunology Letters provides a vehicle for the speedy publication of experimental papers, (mini)Reviews and Letters to the Editor addressing all aspects of molecular and cellular immunology. The essential criteria for publication will be clarity, experimental soundness and novelty. Results contradictory to current accepted thinking or ideas divergent from actual dogmas will be considered for publication provided that they are based on solid experimental findings. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.