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引用次数: 0
摘要
导言:使用爽身粉与癌症(尤其是卵巢癌)之间的联系多年来一直是科学研究和法律辩论的主题。研究表明,长期在生殖器部位使用爽身粉与卵巢癌风险增加之间存在潜在联系:以下报告包括支持使用爽身粉与罹患卵巢癌风险之间潜在联系的最新证据。隶属于世界卫生组织的国际癌症研究机构(International Agency for Research on Cancer)将滑石粉类爽身粉用于女性生殖器部位时可能对人体致癌。然而,其他研究并没有一致支持这种关联,因此需要更多的研究来确定使用爽身粉与癌症之间的明确联系。尽管如此,最近的分子水平数据已将滑石粉与氧化还原平衡的改变、基因突变和炎症反应联系起来。具体来说,我们发现滑石粉可诱导促氧化状态、抑制细胞凋亡,更重要的是可诱导正常卵巢细胞的细胞转化:我们提出了明确的证据来支持我们的观点,即滑石粉不是生物惰性的,它会诱导分子变化,从而模拟癌症的特征。
Is there a link between talcum powder, oxidative stress, and ovarian cancer risk?
Introduction: The link between talcum powder use and cancer, particularly ovarian cancer, has been a topic of scientific research and legal debate for several years. Studies have suggested a potential association between long-term talcum powder use in the genital area and an increased risk of ovarian cancer.
Areas covered: The following report includes up-to-date evidence to support the potential link between talcum powder use and the risk of developing ovarian cancer. The International Agency for Research on Cancer, which is part of the World Health Organization, classified talc-based body powder as possibly carcinogenic to humans when used in the female genital area. However, other studies have not consistently supported this association, and thus more research is needed to establish a clear and definitive link between talcum powder use and cancer. Despite this, recent molecular-level data have linked talc to alterations in redox balance, gene mutations, and inflammatory responses. Specifically, we have identified a role for talc to induce the pro-oxidant state, inhibit apoptosis, and more importantly induced cellular transformation in normal ovarian cells.
Expert opinion: We presented unequivocal evidence to support our opinion that talc is not biologically inert and induces molecular changes that mimic the hallmarks of cancer.
期刊介绍:
Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches.
Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care.
Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections:
Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results
Article Highlights – an executive summary of the author’s most critical points.