作为烟草使用者生物标记物的人体尿液代谢组学:系统综述。

IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Contemporary Clinical Dentistry Pub Date : 2024-01-01 Epub Date: 2024-03-23 DOI:10.4103/ccd.ccd_23_21
Somya Sharma, Shalu Rai, Deepankar Misra, Akansha Misra, Shalini Sharma, Anusuya Sharma, Manish Singh Prayasi
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引用次数: 0

摘要

目的:尿液作为一种生物液体,很少被用作口腔疾病的诊断液体。本文旨在系统回顾人类尿液致癌物代谢物作为获取烟草和癌症重要信息的一种方法的实用性:以下文章回顾了尿液及其代谢物作为生物标记物在包括口腔鳞状细胞癌在内的各种口腔病变中的应用,以及作为评估烟草及其成分的筛查方法的应用。我们在主要数据库中进行了全面的文献检索:PUBMED、SciELO、Google Scholar、VHL 和 LILACS 等主要数据库对 1985 年至 2020 年间发表的文章进行了全面检索。纳入标准为 "尿液代谢物"、"口腔癌/HNSCC"、"体液"、"烟草 "和 "代谢组学"。共收集到 55 篇文章,其中包括实验室研究、系统综述以及关于烟草使用者尿液代谢物的文献:结果:大多数研究显示,尿液代谢物生物标记物对有烟草嗜好的人及其引起的病变具有准确的结果和较高的灵敏度:综述表明,尿液代谢物分析适用于疾病的诊断和预后。尿液是一种非常有用的生物流体,可用于常规检测,并为发现新型生物标记物提供了极好的资源,其优点是采集方便,创伤性小,优于组织活检样本。
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Human Urinary Metabolomics as Biomarkers in Tobacco Users: A Systematic Review.

Aim: Urine as a biofluid has been rarely used as a diagnostic fluid in oral diseases. The article aims to systematically review the utility of human urinary carcinogen metabolites as an approach for obtaining important information about tobacco and cancer.

Materials and methods: The following article reviews the use of urine and its metabolites as biomarkers in various lesions of the oral cavity including oral squamous cell carcinoma and as a screening method in evaluating tobacco and its components. A bibliographic comprehensive search was carried out in the main databases: PUBMED, SciELO, Google Scholar, VHL, and LILACS for articles that were published from 1985 to 2020. The inclusion criteria were "urinary metabolites," "oral cancer/HNSCC," "body fluids," "tobacco," and "metabolomics." A total of 55 articles were collected which included laboratory studies, systematic reviews, and literature of urinary metabolites in tobacco users.

Results: Most of the studies carried out show accurate results with high sensitivity of urinary metabolite biomarkers in individuals with tobacco-based habits and lesions caused by them.

Conclusion: The review indicates that urinary metabolite analysis demonstrates its applicability for the diagnosis and prognosis of disease. Urine is a remarkable and useful biofluid for routine testing and provides an excellent resource for the discovery of novel biomarkers, with an advantage over tissue biopsy samples due to the ease and less invasive nature of collection.

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来源期刊
Contemporary Clinical Dentistry
Contemporary Clinical Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
1.50
自引率
0.00%
发文量
52
审稿时长
23 weeks
期刊介绍: The journal Contemporary Clinical Dentistry (CCD) (Print ISSN: 0976-237X, E-ISSN:0976- 2361) is peer-reviewed journal published on behalf of Maharishi Markandeshwar University and issues are published quarterly in the last week of March, June, September and December. The Journal publishes Original research papers, clinical studies, case series strictly of clinical interest. Manuscripts are invited from all specialties of Dentistry i.e. Conservative dentistry and Endodontics, Dentofacial orthopedics and Orthodontics, Oral medicine and Radiology, Oral pathology, Oral surgery, Orodental diseases, Pediatric Dentistry, Periodontics, Clinical aspects of Public Health dentistry and Prosthodontics. Review articles are not accepted. Review, if published, will only be by invitation from eminent scholars and academicians of National and International repute in the field of Medical/Dental education.
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