哥伦比亚西南部一家综合医院系统性红斑狼疮患者的巨细胞病毒感染和疾病。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY Lupus Pub Date : 2024-07-01 Epub Date: 2024-05-06 DOI:10.1177/09612033241247103
Juan Fernando Contreras-Valero, Ingrid Ruíz-Ordóñez, Gabriel D Pinilla-Monsalve, Mario Bautista-Vargas, Vanessa Ocampo-Piraquive, David Aguirre-Valencia
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引用次数: 0

摘要

巨细胞病毒(CMV)感染和疾病通常发生在免疫力低下的患者身上,但其中患有结缔组织疾病的患者却很少见。在此,我们介绍了 2011 年至 2020 年间在哥伦比亚西南部一家复杂性较高的医院就诊的患有 CMV 感染/疾病的系统性红斑狼疮(SLE)患者的临床、实验室特征、管理和治疗结果。16名系统性红斑狼疮患者被发现患有CMV感染。系统性红斑狼疮的主要特征是肾脏受累(10 名患者;62.50%),14 名患者(87.5%)在感染 CMV 之前接受了类固醇治疗。所有样本都需要入院治疗,主要与急性肾损伤有关,其中九名患者住进了重症监护室(ICU)。胃肠道器官损伤是最常见的 CMV 疾病表现。所有患者均接受了更昔洛韦治疗,其中5人(31.25%)出现脓毒性休克,7人(43.75%)死亡。年龄≥38岁和入院时出现脓毒性休克与死亡结果相关。据我们所知,这是第一份评估哥伦比亚人群中患巨细胞病毒感染/疾病的系统性红斑狼疮患者的出版物。
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Cytomegalovirus infection and disease in systemic lupus erythematosus patients at a high-complexity hospital in southwestern Colombia.

Cytomegalovirus (CMV) infection and disease is a condition usually described in immunocompromised patients, but among them, those with connective tissue diseases are poorly represented. Here we present the clinical, laboratory characteristics, management and outcomes of systemic lupus erythematosus (SLE) patients who presented with a CMV infection/disease to a high complexity hospital in southwestern Colombia between 2011 and 2020. 16 SLE patients were found to have a CMV infection. SLE was predominantly characterized by renal involvement (10 patients; 62.50%), and 14 patients (87.5%) were receiving steroids previous to the CMV infection. The entire sample required hospital admission, mainly related to acute kidney injury, and nine patients were admitted to the intensive care unit (ICU). Gastrointestinal organ damage was the most common CMV disease manifestation. All patients received ganciclovir, five of them (31.25%) suffered from septic shock, and seven (43.75%) died. Age ≥38 years and the presence of septic shock at admission were correlated to the mortality outcome. To our knowledge, this is the first publication evaluating SLE patients with CMV infection/disease in a Colombian population.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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