评估人类乳头瘤病毒相关多型鼻窦癌的一些预后生物标志物

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2024-03-01 DOI:10.30476/IJMS.2023.97341.2906
Mohamed Ali Alabiad, Warda M M Said, Amal M A Adim, Mohammed Alorini, Amany Mohamed Shalaby, Walaa Samy, Shereen Elshorbagy, Doaa Mandour, Ibrahim Mohamed Saber, Amar Ibrahim Omar Yahia, Dina Ahmed Khairy
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引用次数: 0

摘要

背景:人乳头状瘤病毒(HPV)相关多表型鼻窦癌(HMSC)是最近描述的一种预后不明的肿瘤亚型,常与其他鼻窦癌误诊,并与高危HPV(HR-HPV)相关。本研究旨在评估血管内皮生长因子(VEGF)、Bcl-2相关X蛋白(BAX)、表皮生长因子受体(EGFR)、ProExTMC和人类端粒酶逆转录酶(hTERT)的表达,并评估它们与生存和临床病理特征的关系:2017年至2022年间,40名HMSC患者在埃及扎加齐格大学医院医学院(埃及扎加齐格)接受了手术切除。组织样本通过免疫组化检查是否存在HR-HPV;是否存在骨髓母细胞病(MYB)、MYB原癌基因样1(MYBL1)和核因子I/B(NFIB)融合;是否存在肌上皮蛋白(钙蛋白、S100、SMA)、鳞状细胞分化标志物(p63、p40、钙蛋白)、VEGF、BAX、ProExTMC和hTERT。所有患者均接受了约 54 个月的随访,直至死亡或获得最后已知的生存数据。数据采用Chi square检验和Kaplan-Meier法进行分析:结果:VEGF、hTERT和ProExTMC的表达与年龄、肿瘤晚期、淋巴结转移、肿瘤大小、死亡率、复发、无病生存率(DFS)和总生存率(OS)显著相关:HMSC与HR-HPV密切相关。VEGF、表皮生长因子受体(EGFR)、BAX、hTERT和ProExTMC的表达与侵袭性恶性行为、生存率低和预后不良有关,因此成为HMSC靶向治疗的新型预后生物标志物。
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Evaluation of Some Prognostic Biomarkers in Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma.

Background: Human papillomavirus (HPV)-related multi phenotypic sinonasal carcinoma (HMSC) is a recently described tumor subtype with an unknown prognosis, often misdiagnosed with other sinonasal carcinomas, and associated with high-risk HPV (HR-HPV). The present study aimed to evaluate the expression of vascular endothelial growth factor (VEGF), Bcl-2-associated X protein (BAX), epidermal growth factor receptors (EGFR), ProExTMC, and human telomerase reverse transcriptase (hTERT) and assess their association with survival and clinicopathological characteristics.

Methods: Between 2017 and 2022, 40 HMSC patients underwent surgical resection at the School of Medicine, Zagazig University Hospitals (Zagazig, Egypt). Tissue samples were examined for the presence of HR-HPV; absence of myeloblastosis (MYB), MYB proto-oncogene like 1 (MYBL1), and nuclear factor I/B (NFIB) fusions and the presence of myoepithelial proteins (calponin, S100, SMA), squamous differentiation markers (p63, p40, calponin), VEGF, BAX, ProExTMC, and hTERT by immunohistochemistry. All patients were followed up for about 54 months until death or the last known survival data. Data were analyzed using the Chi square test and Kaplan-Meier method.

Results: The expression of VEGF, hTERT, and ProExTMC was significantly associated with age, advanced tumor stages, lymph node metastasis, tumor size, mortality, relapse, poor disease-free survival (DFS), and overall survival (OS) (P<0.001). BAX expression was significantly associated with tumor size, age, poor DFS, and relapse (P=0.01, P<0.001, P=0.035, and P=0.002, respectively).

Conclusion: HMSC is strongly associated with HR-HPV. The expression of VEGF, EGFR, BAX, hTERT, and ProExTMC is associated with aggressive malignant behavior, poor survival, and poor prognosis, making them novel prognostic biomarkers for targeted therapeutics in HMSC.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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