同步双叶与单叶结直肠肝转移的肝切除术:肿瘤结果和患者生存期的回顾性分析。

IF 1.8 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Digestive Surgery Pub Date : 2024-01-01 Epub Date: 2024-05-03 DOI:10.1159/000538359
Christian Stoess, Benjamin Mirschinka, Johanna Ollesky, Marcella Steffani, Nick Seyfried, Benedikt Kaufmann, Helmut Friess, Norbert Hüser, Ulrich Nitsche, Daniel Hartmann
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引用次数: 0

摘要

简介:大肠肝转移瘤切除术已成为标准治疗方法:结直肠肝转移瘤切除术已成为标准治疗方法。我们的研究比较了切除同步双叶与单叶结直肠肝转移瘤患者的肿瘤治疗效果:这项回顾性研究提供了连续 105 例原发性结直肠癌和同步肝转移患者的长期随访数据。所有患者均在 2007 年至 2019 年期间接受了原发肿瘤和转移灶切除术:结果:共纳入55例双叶结直肠癌肝转移患者和50例单叶结直肠癌肝转移患者。双叶和单叶转移患者的总生存期、肿瘤特异性生存期和无复发生存期均无明显差异。经过病例对照匹配后,结果在肿瘤负荷相似的患者中得到了证实。在多变量分析中,肝转移灶切除术后化疗是与总生存率改善相关的重要预后因素(危险比 0.518,95% 置信区间:0.302-0.888,P = 0.017):结论:单叶和双叶肝转移患者的总生存期、肿瘤特异性生存期和无复发生存期没有差异。这些研究结果有助于人们理解,对符合条件的患者进行原发肿瘤和转移瘤切除可改善长期预后。
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Liver Resection in Synchronous Bilobar versus Unilobar Colorectal Liver Metastases: A Retrospective Analysis of Oncological Outcomes and Patient Survival.

Introduction: Resection of colorectal liver metastasis has emerged as the standard treatment. Our study compares oncological outcomes of patients with resected synchronous bilobar versus unilobar colorectal liver metastasis.

Methods: This retrospective study presents long-term follow-up data of 105 consecutive patients with primary colorectal cancer and synchronous liver metastasis. All patients underwent primary tumor and metastasis resections between 2007 and 2019.

Results: Fifty-five patients with bilobar and 50 patients with unilobar colorectal liver metastases were included. No significant difference in overall, tumor-specific, or recurrence-free survival was observed between patients with bilobar and unilobar metastases. After case-control matching, the results were confirmed in patients with similar tumor burdens. In the multivariate analysis, chemotherapy following liver metastasis resection was a significant prognostic factor associated with improved overall survival (hazard ratio 0.518, 95% confidence interval: 0.302-0.888, p = 0.017).

Conclusion: Overall survival, as well as tumor-specific and recurrence-free survival, did not differ between patients with unilobar and bilobar liver metastasis. These findings contribute to the understanding that primary tumor and metastasis resection in eligible patients improve long-term outcomes.

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来源期刊
Digestive Surgery
Digestive Surgery 医学-外科
CiteScore
4.90
自引率
3.70%
发文量
25
审稿时长
3 months
期刊介绍: ''Digestive Surgery'' presents a comprehensive overview in the field of gastrointestinal surgery. Interdisciplinary in scope, the journal keeps the specialist aware of advances in all fields that contribute to improvements in the diagnosis and treatment of gastrointestinal disease. Particular emphasis is given to articles that evaluate not only recent clinical developments, especially clinical trials and technical innovations such as new endoscopic and laparoscopic procedures, but also relevant translational research. Each contribution is carefully aligned with the need of the digestive surgeon. Thus, the journal is an important component of the continuing medical education of surgeons who want their practice to benefit from a familiarity with new knowledge in all its dimensions.
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