Andrea Rossnerova , Irena Chvojkova , Fatima Elzeinova , Daniela Pelclova , Pavlina Klusackova , Vladimir Zdimal , Lucie Ondrackova , Pavel Bradna , Adela Roubickova , Zuzana Simova , Pavel Rossner Jr.
{"title":"牙科纳米复合材料机械加工过程中急性暴露的中年妇女的基因改变图谱。","authors":"Andrea Rossnerova , Irena Chvojkova , Fatima Elzeinova , Daniela Pelclova , Pavlina Klusackova , Vladimir Zdimal , Lucie Ondrackova , Pavel Bradna , Adela Roubickova , Zuzana Simova , Pavel Rossner Jr.","doi":"10.1016/j.etap.2024.104462","DOIUrl":null,"url":null,"abstract":"<div><p>Nanoparticles (NPs) have become an important part of everyday life, including their application in dentistry. Aside from their undoubted benefits, questions regarding their risk to human health, and/or genome have arisen. However, studies concerning cytogenetic effects are completely absent. A group of women acutely exposed to an aerosol released during dental nanocomposite grinding was sampled before and after the work. Exposure monitoring including nano (PM0.1) and respirable (PM4) fractions was performed. Whole-chromosome painting for autosomes #1, #4, and gonosome X was applied to estimate the pattern of cytogenetic damage including structural and numerical alterations. The results show stable genomic frequency of translocations (F<sub>G</sub>/100), in contrast to a significant 37.8% (<em>p</em><0.05) increase of numerical aberrations caused by monosomies (<em>p</em><0.05), but not trisomies. Monosomies were mostly observed for chromosome X. In conclusion, exposure to nanocomposites in stomatology may lead to an increase in numerical aberrations which can be dangerous for dividing cells.</p></div>","PeriodicalId":4,"journal":{"name":"ACS Applied Energy Materials","volume":null,"pages":null},"PeriodicalIF":5.4000,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1382668924001029/pdfft?md5=fc2235f777d0a9363b6c48a967245de1&pid=1-s2.0-S1382668924001029-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Genetic alteration profiling in middle-aged women acutely exposed during the mechanical processing of dental nanocomposites\",\"authors\":\"Andrea Rossnerova , Irena Chvojkova , Fatima Elzeinova , Daniela Pelclova , Pavlina Klusackova , Vladimir Zdimal , Lucie Ondrackova , Pavel Bradna , Adela Roubickova , Zuzana Simova , Pavel Rossner Jr.\",\"doi\":\"10.1016/j.etap.2024.104462\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Nanoparticles (NPs) have become an important part of everyday life, including their application in dentistry. Aside from their undoubted benefits, questions regarding their risk to human health, and/or genome have arisen. However, studies concerning cytogenetic effects are completely absent. A group of women acutely exposed to an aerosol released during dental nanocomposite grinding was sampled before and after the work. Exposure monitoring including nano (PM0.1) and respirable (PM4) fractions was performed. Whole-chromosome painting for autosomes #1, #4, and gonosome X was applied to estimate the pattern of cytogenetic damage including structural and numerical alterations. The results show stable genomic frequency of translocations (F<sub>G</sub>/100), in contrast to a significant 37.8% (<em>p</em><0.05) increase of numerical aberrations caused by monosomies (<em>p</em><0.05), but not trisomies. Monosomies were mostly observed for chromosome X. In conclusion, exposure to nanocomposites in stomatology may lead to an increase in numerical aberrations which can be dangerous for dividing cells.</p></div>\",\"PeriodicalId\":4,\"journal\":{\"name\":\"ACS Applied Energy Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2024-05-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1382668924001029/pdfft?md5=fc2235f777d0a9363b6c48a967245de1&pid=1-s2.0-S1382668924001029-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Energy Materials\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1382668924001029\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Energy Materials","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1382668924001029","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
摘要
纳米粒子（NPs）已成为日常生活的重要组成部分，包括在牙科中的应用。除了毋庸置疑的好处之外，纳米粒子对人类健康和/或基因组的风险问题也随之而来。然而，有关细胞遗传学影响的研究却完全缺失。一组妇女在工作前后被纳米复合材料磨牙过程中释放的气溶胶急性暴露。进行了包括纳米（PM0.1）和可吸入（PM4）部分的暴露监测。对 1 号、4 号常染色体和 X 号染色体进行了全染色体绘制，以估算包括结构和数值改变在内的细胞遗传学损伤模式。结果显示，易位的基因组频率（FG/100）保持稳定，而常染色体 1 号、4 号和 X 号基因组的易位频率则高达 37.8%（p<0.05）。
Genetic alteration profiling in middle-aged women acutely exposed during the mechanical processing of dental nanocomposites
Nanoparticles (NPs) have become an important part of everyday life, including their application in dentistry. Aside from their undoubted benefits, questions regarding their risk to human health, and/or genome have arisen. However, studies concerning cytogenetic effects are completely absent. A group of women acutely exposed to an aerosol released during dental nanocomposite grinding was sampled before and after the work. Exposure monitoring including nano (PM0.1) and respirable (PM4) fractions was performed. Whole-chromosome painting for autosomes #1, #4, and gonosome X was applied to estimate the pattern of cytogenetic damage including structural and numerical alterations. The results show stable genomic frequency of translocations (FG/100), in contrast to a significant 37.8% (p<0.05) increase of numerical aberrations caused by monosomies (p<0.05), but not trisomies. Monosomies were mostly observed for chromosome X. In conclusion, exposure to nanocomposites in stomatology may lead to an increase in numerical aberrations which can be dangerous for dividing cells.
期刊介绍：
ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
